SOY AND ISOFLAVONES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。骨质疏松症是一种主要影响美国老年妇女的疾病。流行病学研究报告称，在亚洲国家，人们摄入的大豆比美国人平均饮食中的大豆含量要高，髋部骨折的发病率有所下降。最近的数据表明，大豆摄入量与亚洲女性的骨密度有关。大豆食品是异黄酮的丰富来源，这些化合物可能是大豆对健康有益的原因。尽管流行病学和初步横断面数据表明大豆可能对骨骼有益（1,2），但很少有良好对照的临床试验完成以充分验证这一理论。许多美国妇女要求对慢性病采取更“自然”的治疗方法，而且相当一部分妇女已经开始食用更多的豆制品或使用异黄酮补充剂。然而，目前尚不清楚这些做法是否对绝经后妇女有益。我们假设，与对照蛋白相比，异黄酮和大豆蛋白对老年妇女的骨骼有有益的影响。此外，我们假设，与对照蛋白或单独的大豆蛋白相比，接受大豆蛋白和异黄酮的女性骨骼会有额外的好处。为了验证这些假设，我们提出了一项为期1年的营养干预研究，研究对象是65岁以上的女性，其中主要的结果指标是骨转换、生活质量、骨密度等生化指标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoporosis is a disease that primarily affects older women in the United States. Epidemiological studies report decreased hip fracture incidence in Asian countries where the population ingests larger amounts of soy than is contained in the average US diet. Recent data suggest that soy intake is correlated with bone mineral density in Asian women. Soy foods are rich sources of isoflavones and these compounds may be responsible for the health benefits of soy. Although epidemiological and preliminary cross-sectional data suggest that soy may be beneficial to bone (1,2), few well-controlled clinical trials have been completed to adequately test this theory. Many women in the United States are demanding more 'natural' treatments for chronic diseases and a substantial proportion of women are already consuming more soy products or using isoflavone supplements. However, it is unclear if these practices are beneficial to postmenopausal women. We hypothesize that isoflavones and soy protein will have a beneficial effect on bone in older women compared to control protein. Further, we hypothesize that there will be an additional benefit to bone in women who receive soy protein plus isoflavones compared to control protein or soy protein alone. In order to test these hypotheses we propose an 1-year nutrition intervention study in women over age 65 years in which the main outcome measures will be biochemical markers of bone turnover, quality of life, bone mineral density.