COMPARISON OF DIETS ON GLYCEMIC CONTROL AND CV RISK FACTORS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。饮食是糖尿病治疗计划的重要组成部分。目前建议糖尿病患者以碳水化合物和单不饱和脂肪的形式摄入每日热量的60-70%。这项建议没有区分高碳水化合物和高单不饱和脂肪饮食。在严格控制的环境下进行的研究显示了高单不饱和脂肪饮食的一些潜在优势，例如改善血液中的脂质水平，在某些情况下，降低血糖水平。目前尚不清楚这些小型短期研究中显示的改善是否能在自由生活的受试者中长期保持。本研究的目的是确定高单不饱和脂肪饮食还是高碳水化合物饮食对2型糖尿病患者更有益。我们将研究一组120名2型糖尿病患者，随机分配高单不饱和脂肪或高碳水化合物饮食一年。我们将确定饮食对以下方面的影响：1)体重；2)身体成分；3)血糖控制；4)心血管风险因素，如血压和血脂。这项研究的结果将为糖尿病患者提供最佳健康饮食建议的关键信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diet is an important component of the treatment plan for diabetes. Patients with diabetes are currently advised to consume 60-70% of their daily calories as carbohydrate and monounsaturated fat. This recommendation makes no distinction between high carbohydrate and high monounsaturated fat diets. Studies performed in carefully controlled settings have shown some potential advantages of high monounsaturated fat diets, such as improvement of lipid levels in the blood and, in some cases, lower blood glucose levels. It is unknown whether the improvements shown in these small, short-term studies could be maintained over longer periods in free-living subjects. The purpose of this study is to determine whether high monounsaturated fat diets or high carbohydrate diets are more beneficial to persons with type 2 diabetes. We will study a group of 120 type 2 diabetic subjects randomly assigned to a high monounsaturated fat or high carbohydrate diet for one year. We will determine the effects of diet on 1) body weight, 2) body composition, 3) blood glucose control, and 4) cardiovascular risk factors, such as blood pressure and plasma lipids. The results of this study will provide critical information about diabetic diet recommendations for optimal health.