CHRONIC KIDNEY DISEASE IN CHILDREN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。美国国家糖尿病、消化和肾脏疾病研究所（NIDDK）肾脏、泌尿和血液疾病科（DKUHD）与美国国家神经疾病和中风研究所（NINDS）、美国国家儿童健康和人类发展研究所（NICHD）和美国国家心肺和血液研究所（NHLBI）合作，资助了一项合作协议，对患有慢性肾脏疾病（CKD）的儿童进行前瞻性流行病学研究。本研究的主要目的是确定肾功能下降的危险因素，并确定肾功能的进行性下降如何影响神经认知功能和行为；心血管疾病的危险因素；生长衰竭及其相关的发病率。具体目标是：确定儿童CKD进展的新型和传统肾脏疾病危险因素（如GFR下降），描述肾功能下降对神经发育，认知能力和行为的影响，确定进行性CKD中传统和新型心血管疾病危险因素的流行和演变，并检查GFR下降对生长和生长衰竭治疗的影响。并评估生长衰竭对慢性肾病患儿发病率的影响。1 - 16岁（在17岁生日之前）患有轻度至中度CKD的儿童将被招募参加本研究。大约540名儿童将在全国57个不同的地点参加这项研究。大约20名儿童将被邀请参加辛辛那提儿童医院医学中心的这项研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung and Blood Institute (NHLBI) funded a cooperative agreement to conduct a prospective epidemiological study of children with chronic kidney disease (CKD). The primary goals of this study are to determine the risk factors for decline in kidney function and to define how a progressive decline in kidney function impacts neurocognitive function and behavior; the risk factors for cardiovascular disease; and growth failure and its associated morbidity. The specific aims are Identify novel and traditional renal disease risk factors for the progression of CKD (e.g. decline of GFR) in children, Characterize the impact of a decline in kidney function on neurodevelopment, cognitive abilities, and behavior, Identify the prevalence and evolution of traditional and novel cardiovascular disease risk factors in progressive CKD, and Examine the effects of declining GFR on growth and the treatment of growth failure, and to assess the consequences of growth failure on morbidity in children with CKD. Children 1 to 16 years old (before 17th birthday) with mild to moderate CKD will be recruited for this study. About 540 children will be in this study at 57 different sites around the country. About 20 children will be asked to be in this study at Cincinnati Children's Hospital Medical Center.