CLINICAL EVALUATION OF A NANO HYBRID COMPOSITE RESIN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在美国，80%的牙医使用后牙树脂复合材料。1971年发表了第一次后复合材料临床试验的结果。随后召回的相同涂层显示，树脂复合涂层的耐磨性较差。早期的综述建议，复合材料仅限于保守的双尖牙和第一磨牙，其中美学是关键。尽管树脂复合材料有了改进，但材料的局限性限制了树脂复合材料作为后牙修复材料的使用。在临床上，树脂修复是困难的，需要更多的放置时间比类似大小的银汞合金修复。由于复合材料是一种在聚合过程中收缩的糊状材料，因此难以获得邻间接触;两项临床研究报告称，20%的后部复合材料矫正中存在接触不良或接触缺陷。 复合树脂修复体的临床问题是复发性龋的发生主要是由于聚合物的收缩和修复体龈腔面边缘的开放。目前，诊断邻间复发性龋的最佳方法是咬翼片，其记录脱矿（釉质和牙本质的矿物质含量的损失）作为放射密度的相应降低。需要进一步开发具有更高耐磨性、降低聚合收缩和改进的粘合剂系统的复合树脂，该粘合剂系统具有与牙齿结构更强的粘合。本研究将评价放置在1类和2类制剂中的聚合收缩减少的复合材料的临床成功，以评价复合材料是否将通过美国牙科协会建立的认证计划。 具体目标：1。为了将复合树脂放置在I类和II类腔体制备物中，根据特定标准（直接和间接）评价基线、6个月、1年和18个月时的树脂复合材料固化。2.评价树脂复合材料的染色、边缘完整性、对冷的反应、放置时间和近端接触18个月。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Posterior resin composites are used by 80% of the dentists practicing in the United States. The results of the first clinical trial of posterior composites were published in 1971. Subsequent recalls of the same restorations revealed that the resin composite restorations had poor wear resistance. Early reviews recommended that composite be limited to conservative bicuspid and first molar restorations where esthetics was critical. In spite of improvements in resin composites, material limitations exist which restrict the use of resin composite as a posterior restorative material. Clinically, resin restorations are difficult and require more placement time tkhan a similar sized amalgam restoration. Interproximal contacts are difficult to obtain since composite is a paste material that shrinks during polymerization; two clinical investigations reported weak or defective contacts in 20% of the posterior composite restorations. The development of recurrent caries is a clinical problem with composite resin restorations primarily due to polymerization shrinkage and opening of the restoration gingival cavosurface margins. At present, the best means of diagnosing interproximal recurrent caries is with bitewing radiographs, which records demineralization (the loss of mineral content of the enamel and dentin) as a corresponding decrease in rediographic density. Further developments of composite resin with more wear resistance, reduced polymerization shrinkage and improved adhesive systems with stronger bonds to tooth structure are needed. This study will evaluate the clinical success of a composite with reduced polymerization shrinkage placed in class 1 and class 2 preparations to evaluate whether the composite will pass the certification program established by the American Dental Association. Specific Aims: 1. To place a composite resin in Class I and Class II cavity preparations, evaluate the resin composite restorations at baseline, 6 months, 1 year, and 18 months for specific criteria (direct and indirect). 2. To evaluate the resin composite restorations for staining, marginal integrity, response to cold, placement time, and proximal contact for 18 months.