OUTCOME OF PTS TREATED IN EMERGENCY DEPARTMENT AFTER MOTOR VEHICLE COLLISION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。创伤事件后，个人往往会出现慢性问题。以往的研究表明，在轻微的机动车碰撞（MVC）后，高达1/3的患者会出现心理后遗症，包括创伤后应激障碍、抑郁症和焦虑症。此外，10-30%的患者会出现慢性局部疼痛（颈部或背部疼痛）。尽管它们很常见，但对这些疾病的风险因素和疾病发展过程仍然知之甚少。拟议的研究旨在通过对轻微MVC创伤后患者结局的全面检查，在这些领域获得重要的新认识。将从2个当地急诊科招募600名18岁或以上的妇女。同意参加艾德研究的患者将接受30-45分钟的艾德评估，评估与撞车相关的心理社会和生物因素，并在1个月和6个月时完成邮件/电话随访。那些拒绝参加的人将被询问他们是否愿意在6个月时接受1次随访电话，以了解他们的情况。将询问完成艾德评估方案的患者是否有兴趣接收关于在门诊进行的单独相关随访研究的信息。患者将在MVC后3-7天返回研究诊所，并进行更详细的评估，包括更深入的心理社会和生物因素评估，以及疼痛和心理处理的功能MRI评估。有症状的患者将在1个月、3个月和6个月时继续返回门诊进行进一步评估。最初来研究诊所但随后康复的患者将通过邮件/电话在1个月和/或6个月时完成随访。从本研究中获得的丰富信息将用于识别高风险患者，了解疾病机制，并开发二级药理学和/或行为干预措施，以预防创伤事件后的慢性疼痛和心理后遗症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Individuals often develop chronic problems after traumatic events. Previous studies have shown that after minor motor vehicle collision (MVC), up to 1/3 of patients will develop psychological sequelae, including posttraumatic stress disorder, depression, and anxiety disorders. In addition, 10-30% of patients develop chronic regional pain (neck or back pain). Despite their common occurrence, the risk factors and processes of disease development for these disorders remain poorly understood. The proposed study seeks to gain important new understanding in these areas, through a comprehensive examination of patient outcomes after minor MVC trauma. 600 women e18 years of age or older will be recruited from 2 local emergency departments. Patients who consent to the ED study will undergo a 30-45 minute ED assessment of crash-related, psychosocial, and biological factors, and complete mail/telephone follow-up at 1 and 6 months. Those who decline participation will be asked if they would be willing to receive 1 follow-up phone call at 6 months to see how they are doing. Patients who complete the ED assessment protocol will be asked if they would be interested in receiving information regarding a separate, related follow-up study conducted in an outpatient clinic. Consenting patients will return to the research clinic 3-7 days after the MVC, and will have a more detailed evaluation, including a more in-depth evaluation of psychosocial and biological factors, and functional MRI assessment of pain and psychological processing. Patients who are symptomatic will continue to return to the outpatient clinic for further evaluations, at 1 month, 3 months, and 6 months. Patients who initially come to the research clinic, but subsequently recover, will complete follow-up at 1 month and/or 6 months via mail/telephone. The wealth of information gained from this study will be used to identify high risk patients, understand mechanisms of disease, and develop secondary pharmacologic and/or behavioral interventions to prevent chronic pain and psychological sequelae after traumatic events.