HF ACTION FOR HEART FAILURE AND A CONTROLLED TRIAL INVESTIGATING OUTCOMES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。超过470万美国人患有心力衰竭（HF），每年新增病例40万例。虽然更多的人在心脏病发作中幸存下来，但许多人后来发展为HF。不幸的是，HF的死亡率持续增加，并且用于HF的医疗保险资金比心脏病发作和癌症治疗的总和还要多。这种疾病对生活质量有巨大的影响，这可能是由运动不耐受引起的。随着病情的发展，患者变得更加虚弱。多年来，许多研究已经检查了HF患者运动不耐受的机制。需要发现EF和运动不耐受之间的相关性，导致研究人员寻找HF患者疲劳的原因。HF-ACTION旨在检验以下主要假设：纽约心脏分级为II-IV级的HF患者，在常规治疗的基础上接受运动训练，2年内的死亡率和住院率比仅接受常规治疗的患者低20%。这项研究将包括3,000名受试者，他们将接受3年以上的随访;一半随机接受常规护理，一半随机接受锻炼计划。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over 4.7 million Americans suffer from heart failure (HF) with 400,000 new cases each year. Although more people are surviving a heart attack, many later develop HF. Unfortunately, mortality from HF continues to increase and more Medicare dollars are spent on HF than heart attacks and cancer therapy combined. This disease has a tremendous impact on quality of life, which can be caused by exercise intolerance. As the disease progresses, patients become more debilitated. Over the years many studies have examined the mechanisms responsible for exercise intolerance in HF patients. The need to discover the correlation between EF and exercise intolerance has lead investigators to search for an explanation for the cause of fatigue observed in HF patients. The HF-ACTION is designed to test the primary hypothesis that patients with HF with a New York Heart Classification of II-IV, who are given an exercise training program in addition to usual care, will have a 20% lower rate of death and hospitalization over 2 years than those who receive usual care alone. This study will include 3,000 subjects who will be followed over 3 years; half randomized to usual care and half randomized to an exercise program.