OSTEOPOROSIS IN PEDIATRIC BONE MARROW TRANSPLANT PATIENTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。患有肿瘤疾病（如白血病和实体瘤）的儿科患者骨密度（BMD）降低的风险增加。然而，在原发性肿瘤诊断后接受骨髓移植的儿童中BMD降低的具体患病率尚不清楚。然而，在成年人中，骨髓移植是已知的骨质疏松症/骨质减少症的重大风险。此外，我们不知道决定哪些接受骨髓移植的儿科患者骨量发育受损的具体风险因素。这是很重要的，因为峰值骨量是在青春期达到的，而进入成年期时骨密度低是已知的成年骨质疏松症和骨脆性的重大风险。 这项横断面研究将通过测量处于骨髓移植不同阶段的受试者全身和腰椎的DEXA扫描来评价儿科骨髓移植受试者的骨密度。我们将对移植前至移植后数年的受试者进行评估。此外，我们将评估该人群骨密度降低的潜在原因，包括类固醇治疗、化疗和放疗方案、负重活动、钙摄入和内分泌功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pediatric patients with oncologic conditions, such as leukemia and solid tumors, have a well-documented increase in the risk of decreased bone mineral density (BMD). However, the specific prevalence of decreased BMD in children undergoing the added stress of bone marrow transplant after a primary oncologic diagnosis is not known. Among adults, however, bone marrow transplant is known to be a significant risk for osteoporosis/osteopenia. Furthermore, we do not known the specific risk factors that determine which pediatric patients undergoing bone marrow transplant will have impaired bone mass development. This is significant, as peak bone mass is achieved in adolescence, and entering adulthood with low bone mineral density is known to be a significant risk for adult osteoporosis and bone fragility. This cross-sectional study will evaluate bone density in pediatric bone marrow transplant subjects by measuring DEXA scans of total body and lumbar spine in subjects who are at different stages of bone marrow transplant. We will evaluate subjects from pre-transplant to several years post-transplant. Additionally, we will evaluate potential causes of decreased bone density in this population, including steroid therapy, chemotherapy and radiation therapy regimens, weight-bearing activity, calcium intake, and endocrinologic dysfunction.