GASTRIC BYPASS EFFECTS ON SLEEP & GLUCOSE REG

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。临床观察表明，胃旁路手术后几天，患者睡眠更好，嗜睡感更少。在体重显著减轻之前。其机制尚不清楚。拟议的研究将测试假设，即改善葡萄糖耐量是胃旁路术对睡眠和嗜睡的快速影响的机制。接受briatric手术的患者将在两个独立的8天住院期间进行研究，一个在手术前，一个在手术后。在这两种情况下，饮食摄入量将限制在1,200千卡，并严格控制。在两项研究开始和结束时，将评估睡眠、嗜睡和葡萄糖耐量参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Clinical observations suggest that patients sleep better and feel less sleepy a few days after gastric bypass, ie. Before significant weight reduction. The mechanism is not known. The proposed studies will test the hypotesis that improved glucose tolerance is the mechanism underlying rapid effect of gastric bypass on sleep and sleepiness. Patients undergoing briatric surgery will be studied during two separate 8-day inpatient admissions, one before surgery and one after surgery. On both occasions, dietary intake will be limited to 1,200 Kcal and strictly controlled. Sleep, sleepiness and parameters of glucose tolerance will be assessed at the beginning and at the end of both study p