CARDIAC MRI IN DIAGNOSIS OF CARDIAC AMYLOIDOSIS (PILOT STUDY)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这项初步观察性研究旨在确定对比延迟增强（CDE）心脏磁共振成像（CMR）是否对异常蛋白质沉积和周围纤维化敏感，从而可用于心脏淀粉样变性的早期诊断。研究者将检查CDE量与左心室收缩功能、舒张功能障碍、心室质量和厚度、心房大小或血清和尿液中免疫球蛋白轻链量的相关性。10例经活检和超声心动图证实的淀粉样变患者将接受

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot observational study seeks to determine whether contrast delayed enhancement (CDE) cardiac magnetic resonance imaging (CMR) is sensitive to abnormal protein deposition and surrounding fibrosis and can thus be used for the early diagnosis of cardiac amyloidosis. The investigators will examine correlations of the amount of CDE with left ventricular systolic function, diastolic dysfunction, ventricular mass and thickness, atrial size, or quantities of immunoglobulin light chains in serum and in urine. Ten patients with amyloidosis demonstrated through biopsy and echocardiogram will undergo