INSULIN RESISTANCE IN ADOLESCENTS AT HIGH RISK FOR POLYCYSTIC OVARY SYNDROME

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。多囊卵巢综合征(PCOS)影响全球5%-10%的育龄妇女，导致慢性无排卵，加速2型糖尿病及其前驱疾病的发病。我们假设胰岛素的异常作用先于并促进了成年多囊卵巢综合征患者的生殖功能障碍。我们将对比有记录的多囊卵巢综合征家族中的女孩在整个青春期对胰岛素的敏感性的模式，并确定青春期胰岛素作用障碍是否预示着多囊卵巢综合征的最终表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) affects 5-10% of reproductive-aged women worldwide, resulting in chronic anovulation and an accelerated onset of type 2 diabetes and its precursors. We hypothesize that aberrant insulin action precedes and facilitates the reproductive dysfunction seen in adult PCOS. We will contrast the patterns of insulin sensitivities throughout puberty in girls from families with documented PCOS, with and without associated glucose intolerance, to determine whether pubertal disorders of insulin action predict eventual expression of PCOS.