PARTIAL GROWTH HORMONE INSENSITIVITY IN IDIOPATHIC SHORT STATURE/SMALL-FOR-GESTA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目旨在调查特发性矮小(ISS)和(或)出生小于胎龄(SGA)儿童的部分生长激素不敏感(GHI)。我们建议结合功能、生化和分子研究，为患有部分GHI的ISS和/或SGA儿童确定最可靠的标志物，以便让他们接受适当的生长激素治疗(生长激素剂量高于生长激素缺乏儿童)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is to investigate partial growth hormone insensitivity (GHI) among children with idiopathic short stature (ISS) and/or born small-for-gestational age (SGA). We propose to integrate functional, biochemical and molecular studies to identify the most reliable markers for children with ISS and/or SGA that have partial GHI in order to put them on appropriate growth hormone treatment (higher growth hormone doses than are given to growth hormone deficient children).