LOW CARBOHYDRATE ON FASTING AND POST FAT LOAD LIPOPROTEINS OF DIABETICS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在中度高甘油三酯血症的糖尿病患者中，改变饮食为高单不饱和脂肪/低碳水化合物(HFLC)饮食(空腹甘油三酯300 800 mg/dl)将比改变为低脂肪/高碳水化合物(LFHC)饮食更能降低空腹甘油三酯(TG)。目的1是确定用低脂饮食或高脂饮食治疗中度高甘油三酯血症的糖尿病患者的空腹甘油三酯的变化。在有中度高甘油三酯血症的糖尿病患者中，改变饮食为高脂饮食将比改变低脂肪饮食更能降低餐后甘油三酯和富含甘油三酯的脂蛋白(TRL)。目的2研究标准脂肪餐对中度高甘油三酯血症的糖尿病患者餐后甘油三酯(TG)和总胆固醇(TRL)的影响。大约14名患有2型糖尿病和空腹甘油三酯300-800 mg/dl的受试者，男性或女性，年龄18-75岁，将被随机分配。在筛查访问之后，受试者最初将被随机分为LFHC或HFC体重维持饮食。LFHC饮食将由30%的脂肪(10%单不饱和，10%饱和，10%多不饱和)，55%的CHO和15%的蛋白质组成。HFL饮食将是等热量的，提供40%的CHO，45%的脂肪(25%单不饱和脂肪，10%饱和脂肪，10%多不饱和脂肪)和15%的蛋白质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Changing the diet to a high monounsaturated fat/low carbohydrate (HFLC) diet in diabetics with moderate hypertriglyceridemia (fasting triglycerides 300 800 mg/dl) will decrease the fasting triglycerides (TG) more than changing to a low fat/high carbohydrate (LFHC) diet. Aim 1 is to determine the change in fasting TG in diabetics with moderate hypertriglyceridemia treated with a LFHC or a HFLC diet. Changing the diet to a HFLC diet in diabetics with moderate hypertriglyceridemia will decrease postprandial TG and triglyceride rich lipoproteins (TRL) after a standard fat meal more than changing to a LFHC diet. Aim 2 is to determine the change in postprandial TG and TRL after a standard fat meal in diabetics with moderate hypertriglyceridemia treated with a LFHC diet or a HFLC diet. Approximately 14 subjects, male or female 18 75 years of age, with type 2 diabetes and fasting triglycerides 300 - 800 mg/dl will be randomized. Following the screening visit, subjects will be initially randomized to either LFHC or HFLC weight maintenance diets. The LFHC diet will consist of 30% fat (10% monounsaturated, 10% saturated, 10% polyunsaturated), 55% CHO and 15 % protein. The HFLC diet will be isocaloric and provide 40% CHO, 45% fat (25% monounsaturated, 10% saturated, 10% polyunsaturated fat) and 15% protein.