RESTORATION OF FOREARM AND ELBOW FUNCTION BY FNS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是探讨C5和C6脊髓损伤患者上肢神经假体刺激肘关节伸展的强度和可控性的最大化方法。我们假设，增强已建立的手部抓取神经假体将使这些个体能够在更大的空间位置和方向上抓取和移动物体，并提高他们进行重量转移和滑动转移的能力。现有的手抓神经假体将通过在瘫痪的三头肌中植入16通道植入式接收器/刺激器（IRS）来增强，以恢复肘部控制和手抓/释放。术后固定以使患者充分愈合后，将评估受试者植入装置的性能、运动和感觉功能的变化，以及他们带器械的手和手臂的功能使用。后者将通过使用手和手臂功能的定性和定量测量来评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this work is to investigate methods of maximizing the strength and controllability of stimulated elbow extension for subjects with C5 and C6 spinal cord injuries who have upper extremity neuroprosthesis. We hypothesize that augmenting an established hand grasp neuroprosthesis will give these individuals the ability to grasp and move objects over a greater range of spatial locations and orientations, and improve their ability to perform weight shifts and sliding transfers. The existing hand grasp neuroprosthesis will be augmented by surgical placement of a 16-channel implantable receiver/stimulator (IRS) in the paralyzed triceps in order to restore elbow control in addition to hand grasp/release. Following post-surgical immobilization to allow for adequate healing, subjects will be evaluated for performance of the implanted device, for changes in motor and sensory function, and for functional use of their instrumented hand and arm. The latter will be assessed through use of qualitative and quantitative measures of hand and arm function.