KAINIC ACID DERIVATIVES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。乔尼博士将开发一个独立的研究项目，利用立体支撑物来制造红藻氨酸。红藻氨酸及其衍生物是一种有效的GABA模拟物，具有神经兴奋剂、杀虫剂和抗蠕虫药物等生物活性。海人酸衍生物作用于谷氨酸能突触和GABA突触。注射红藻氨酸后的神经细胞死亡已被认为是老年性痴呆神经细胞丢失的一个重要模型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Choony will be developing an independent research program in the use of steric buttresses to make kainic acid. Kainic acid and its derivatives are potent GABA-mimetics, showing bioactivity as neuroexcitatory agents, insecticides, and antihelminthics. Kainic acid derivatives act on both glutaminergic and GABA synapses. Neuronal cell death following injection of kainoids has been proposed as an important model for the neuronal cell loss observed in senile dementia.