NEUROREHABILITATION THERAPEUTICS IN STROKE PATIENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的目标是证明通过与三个跨学科小组（即生物信息学/计算机科学；生物/行为科学；工程/行为科学）的合作努力开发的各种培训干预措施的可行性，并根据与熟练动作学习相关的原则提供信息。研究1代表了该跨学科研究探索中心所涵盖的中风神经康复新方向发展的人体临床试验平台。研究1的一个必然目的是通过我们的重复测量fMRI设计，通过三个手部灵巧任务-力量掌握，精确掌握和顺序手指敲击来表征训练诱导的功能性脑激活变化。我们期望我们的行为干预的调节效果会随着病变位置和大小、时间（急性、慢性）和动机的变化而变化

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to demonstrate the feasibility of various training interventions that have been developed through collaborative efforts with the three interdisciplinary groups (i.e., bioinformatics/computer science; biological/behavioral science; and engineering/behavioral science) and informed by the principles associated with the learning of skilled actions. Study 1 represents the human clinical test-bed for the development of new directions in stroke neurorehabilitation encompassed by this Exploratory Center for Interdisciplinary Research. A corollary aim of Study 1is to characterize the training-induced functional brain activation changes using our repeated measures fMRI design through three hand dexterity tasks--power grasp, precision grasp, and sequential finger tapping. We expect that the modulatory effects of our behavioral interventions will vary as a function of lesion locations and size, timing (acute, chronic), and motivat