Interactions between Notch signalling and SoxB transcription factors during the development and regeneration of sensory hair cells

内耳包含不同的感觉器官，负责听觉和头部运动的感知。每个感觉器官都包含有限数量的感觉细胞，称为毛细胞。在哺乳动物中，噪声创伤、耳毒性或衰老过程中听觉毛细胞的丧失是不可逆的，并导致永久性耳聋。但在鸟类、鱼类和两栖动物中，内耳毛细胞在整个生命过程中都会产生，并在组织损伤后再生。我们的主要目标是确定基因和信号参与毛细胞的生产过程中胚胎发育和创伤后再生鸡内耳。从长远来看，我们的发现可能有助于开发新的耳聋疗法。

The inner ear contains different sensory organs responsible for hearing and the perception of head movements. Each sensory organ contains a limited number of sensory cells, named hair cells. In mammals, the loss of auditory hair cells following a noise trauma, ototoxicity, or during aging is irreversible and causes permanent deafness. But in birds, fish and amphibians, inner ear hair cells are produced throughout life and regenerate following tissue injury. Our main objective is to identify the genes and signals involved in the production of hair cells during embryonic development and their post-traumatic regeneration in the chick inner ear. In the long term, our findings could contribute to the development of new therapies for deafness.