HIV INTEGRASE SH3 INTERACTIONS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。HIV整合酶是病毒的第三种酶（另外两种是逆转录酶和蛋白酶）。HIV利用整合酶将其基因整合到宿主细胞的DNA中。抑制HIV整合酶是一种有吸引力的治疗策略，因为它可能保护健康细胞免受感染，从而有助于增强免疫系统。我们目前正在研究整合酶SH3的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV integrase is the virus's third enzyme (the other two are reverse transcriptase and protease). HIV uses integrase to incorporate its genes into a host cell's DNA. Inhibition of HIV integrase is an attractive therapeutic strategy since it would potentially protect healthy cells from infection thereby helping to bolster the immune system. We are currently investigating integrase SH3 interactions.