COMBINATORIAL SYNTHESIS OF PHOSPHINE LIGANDS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们的研究集中在新的合成方法的开发和利用合成化学的重要生物和医学问题的研究。我们实验室的项目范围从有机合成新方法的开发和生物重要天然产物的全合成到围绕先导化合物的药物化学。在UTMB进行合成化学为我们提供了一个独特的机会来测试我们化合物的生物活性并进行修饰以提高活性或测试重要的生物学原理。我们目前正在开展的一些项目是：小分子库合成化学的开发生物重要天然产物的全合成和药物化学铑催化合成中等大小的环肽基催化剂

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research is centered on the development of new synthetic methods and the utilization of synthetic chemistry for the study of important biological and medical problems. The projects in our laboratory range from the development of new methods in organic synthesis and the total synthesis of biologically important natural products to medicinal chemistry around leads compounds. Doing synthetic chemistry at UTMB provides us with a unique opportunity to test the biological activity of our compounds and make modifications to improve activity or test important biological principles. Some of the projects we are currently working on are: Development of chemistry for small molecule library synthesis Total synthesis and medicinal chemistry of biologically important natural products Rhodium catalyzed synthesis of medium sized rings Peptide based catalysts