Hematopoietic transplants from autologous pluripotent cell sources

这项建议调查了两种类型的患者来源的干细胞用于移植到血液中的用途。这些干细胞是从皮肤细胞等特殊组织中重新编程的诱导多能干细胞，以及仅使用卵母细胞或精子(单亲胚胎)遗传物质衍生的干细胞。利用小鼠，我们正在观察这些细胞在移植后形成正常血统的能力，以及在贝塔-地中海贫血小鼠模型中修复血液的能力。

This proposal investigates the utility of two types of patient-derived stem cells for transplantation into blood. These are induced pluripotent stem cells that are reprogrammed from specialized tissues such as skin cells, and stem cells derived using the genetic material of oocytes or sperm only ( one-parent embryos). Using the mouse, we are looking at the ability of these cells to form normal blood lineages after transplantation, and to repair blood in a mouse model for beta-thalassemia.