Identification of Structure-Based Antisickling Peptides that Inhibit HBS Polymeri

镰状细胞病(SCD)是非洲最常见的严重遗传病。在加纳，2% 的新生儿被发现患有纯合型SCD(SCD-SS)或镰状细胞病-SC病 (SCD-SC)。在美国和非洲以外的其他地方，细菌感染，特别是肺炎球菌 败血症和脑膜炎是SCD儿童死亡的主要原因。儿童死亡率 肺炎球菌败血症在美国通过早期诊断已降至较低水平 新生儿接受青霉素预防、抗肺炎球菌疫苗接种和健康教育。 家长和卫生工作者对这个问题的看法。在非洲，据报道，感染也是 儿童SCD的主要死因。然而，感染的原因及其相关因素 重要性并没有得到准确的确定。肺炎球菌感染在普通人群中非常普遍。 在非洲儿童人口中，但关于其在儿童中的意义，有相互矛盾的数据 SCD。青霉素预防和肺炎球菌疫苗接种在幼儿中并不广泛使用。 在非洲的SCD。宿主报告将疟疾列为#年SCD儿童死亡的主要原因 非洲。然而，急性疟疾感染的发病率和与之相关的危险因素 患有SCD的儿童中的疟疾尚未得到描述。没有实行抗疟疾预防措施 统一适用于非洲所有患有SCD的儿童。 在这项研究中，将监测一组从出生起就被诊断为SCD的幼儿。 密切处于稳定状态和急性疾病期间，以便收集预期的临床和实验室 数据并确定发烧和感染的原因。家长将接受培训，以测量 体温和识别其他感染迹象，并带生病的儿童进行评估和 管理层。将采用家访的方式来监视家中的儿童并加强教育。 和预防性护理。将进行血液培养、疟疾涂片和血液学检查， 在急病期间。将实施协议以确保提供及时管理 所有可能有细菌或急性疟疾感染的受试者。的发病率和流行率 将确定细菌和疟疾感染及其相关风险因素。

Sickle cell disease (SCD) is the most common serious genetic disease in Africa. In Ghana, 2% of newborns have been found to have homozygous SCD (SCD-SS) or sickle cell disease-SC disease (SCD-SC). In the U.S. and elsewhere outside Africa, bacterial infections, particularly pneumococcal sepsis and meningitis, are the leading cause of death in children with SCD. Childhood mortality from pneumococcal sepsis has been reduced to low levels in the U.S. through early diagnosis in the newborn followed I_ypenicillin prophylaxis, anti-pneumococcal vaccination, and education of parents and health workers about this problem. In Africa, infections are also reported to be the leading cause of death in children with SCD. However, the causes of infection and their relative importance are not precisely determined. Pneumococcal infection is highly prevalent in the general childhood population in Africa, but there are conflicting data on its significance in children with SCD. Penicillin prophylaxis and pneumococcal vaccination are not widely used in young children with SCD in Africa. Host reports list malaria as the leading cause of death in children with SCD in Africa. However, the incidence of acute malaria infection and the risk factors associated with malaria in children with SCD have not been described. Anti-malarial prophylaxis is not practiced uniformly for all children with SCD in Africa. In this study, a cohort of young children with SCD diagnosed from birth will be monitored closely at steady state and during acute illness in order to collect prospective clinical and laboratory data and determine the causes of fever and infection. Parents will be trained to measure temperature and recognize other signs of infection and to bring ill children for evaluation and management. Home visits will be employed to monitor children at home and to reinforce education and preventive care. Blood cultures, malarial smears and hematologic studies will be obtained , during acute illness. Protocols will be implemented to ensure that prompt management is provided all subjects with potential bacterial or acute malarial infection. Incidence and prevalence of bacterial and malarial infections and their associated risk factors will be determined.