Core--Animal Model Laboratory

动物模型实验室核心将与SPIRP调查人员合作，进一步了解 高血压和其他特殊血管危险因素在高血压病病理生理学中的作用 脑血管疾病。动物实验室的长期目标是进一步了解高血压和其他特定血管危险因素在脑血管疾病病理生理中的作用。该实验室将与SPIRP的其他组成部分相结合，以支持在制定旨在预防中风和其他脑血管疾病的措施时在床边应用基本科学原理。第一阶段的具体目标是1)在MSM-SPIRP内建立一个由研究人员组成的互动工作组，他们对开发治疗中风的新方法有共同的兴趣 通过进一步阐明中风易感性、神经保护和血管性痴呆的病理生物学来预防，2)在实验性中风、神经保护和血管生物学方面具有专业知识的莫尔豪斯医学院研究人员与在磁共振成像和行为神经科学方面具有专业知识的埃默里大学研究人员开展合作，3)优化磁共振成像方案，以使用具有良好特征的中风模型：大脑中动脉闭塞模型来测量脑损伤和脑血流的变化，4)通过体内MR等补充方法来表征高血压相关脑微血管疾病的模型及其对脑结构和功能的影响 5)使用Dahl盐敏感大鼠模型进行卒中预防研究；5)使用Dahl盐敏感大鼠模型和SPIRP、神经科学研究所和心血管研究所支持的研究人员使用或开发的其他动物模型支持进一步的中风预防研究。第二阶段的具体目标将是1)根据第一阶段的研究结果实施神经保护干预实验方法，以及2)促进将脑缺血基础研究的结果应用于临床干预研究。

The Animal Model Laboratory Core will work with SPIRP investigators to further understand the contribution of hypertension and other specific vascular risk factors to the pathophysiology of cerebrovascular disease. The long-term goal of the animal laboratory is to further understand the role of hypertension and other specific vascular risk factors in the pathophysiology of cerebrovascular disease. This laboratory will be integrated with the other components of the SPIRP in order to support bench-to-bedside application of basic scientific principles in the development of measures designed to prevent stroke and other cerebrovascular disease. The specific aims in Phase I will be 1) to establish an interactive working group of investigators within the MSM-SPIRP who share an interest in developing novel approaches to stroke prevention by further elucidating the pathobiology of stroke susceptibility, neuroprotection and vascular dementia, 2) to develop collaborations between Morehouse School of Medicine investigators, with expertise in experimental stroke, neuroprotection, and vascular biology, and Emory University investigators with expertise in magnetic resonance imaging and behavioral neuroscience, 3) to optimize MR imaging protocols to measure brain injury and changes in cerebral perfusion using a well-characterized stroke model: the middle cerebral artery occlusion model, 4) to characterize a model of hypertension-related cerebral microvascular disease and its effect on brain structure and function by complementary methodologies such as in vivo MR imaging using the Dahl salt-sensitive rat model, and 5) to support further stroke prevention studies using the Dahl salt-sensitive rat model and other animal models used or developed by SPIRP-, Neuroscience Institute-, and Cardiovascular Research Institute-supported investigators focused on understanding the mechanisms and prevention of cerebrovascular disease. The specific aims in Phase II will be 1) to implement neuroprotective intervention experimental approaches based upon outcomes of studies from Phase I, and 2) to facilitate the application of findings from basic research on cerebral ischemia to clinical intervention research.