CENTER OF CLINICAL RESEARCH EXCELLENCE

本提案的总体目标是在夏威夷大学（UH）建立一个临床研究卓越中心（CCRE），作为对现有RCMI临床研究中心（CRC）的补充。CCRE的目标是通过支持有前途的初级研究人员的职业发展，特别是那些研究重点是严重影响夏威夷少数民族人口的健康问题的研究人员，来增加夏威夷州职业临床研究人员的队伍。 这些初级研究人员的职业发展将通过与提供基础和临床科学专业知识的高级研究人员合作，以及通过招募到该机构的杰出（磁铁）研究人员的指导来促进，他们也将通过建立自己的研究计划为研究工作做出贡献。在夏威夷大学建立社区康复中心将有助于实现2010年健康人民国家议程的目标，支持临床研究，解决夏威夷州少数民族人口的健康差距问题。为了实现这一目标，这项建议的具体目标是：1）招募杰出的（磁铁）研究人员到大学; 2）支持对临床研究事业感兴趣的初级UH教师的发展; 3）建立一个国家的最先进的研究实验室教师，以支持CCRE研究人员，研究员和工作人员;和4）促进并主要领导夏威夷大学促进临床研究的长期计划的整体发展。夏威夷大学的情况是独一无二的。远离美国本土，由于其在太平洋的地理隔离，合作和隶属关系，可以自然地在社区环境中与邻近大学的发展是不可能在夏威夷。该CCRE为夏威夷大学提供了一个现实的机会，以开发一个强大的临床研究计划，该计划将通过招募高级科学家，初级研究人员的成功职业发展，以及与华盛顿大学和其他西海岸机构的强有力的合作和联系的发展，继续扩展到NIH支持的持续时间之外。该CCRE将提供必要的领导和远见，利用研究投资所作出的研究投资，为下一代的临床研究人员在夏威夷大学的发展。

The overall goal of this proposal is to establish a Center of Clinical Research Excellence (CCRE) at the University of Hawaii (UH) as a complement to the existing RCMI Clinical Research Center (CRC). The objective of the CCRE is to increase the cadre of career clinical researchers in the State of Hawaii by supporting the career development of promising junior investigators, particularly those whose research focuses on health problems disparately affecting Hawaii's minority populations. The career development of these junior investigators will be fostered through collaborations with senior investigators offering expertise in both basic and clinical science, as well as through mentoring from distinguished (magnet), investigators recruited to the institution, who will also contribute to the research effort with the establishment of their own research programs. The establishment of a CCRE at the University of Hawaii will contribute to the goals of the Healthy People 2010 national agenda by supporting clinical research that addresses the health disparities of the minority populations in the State of Hawaii. To accomplish this objective, the specific aims of this proposal are: 1) To recruit distinguished (magnet) investigators to the University; 2) To support the development of junior UH faculty interested in clinical research careers; 3) To establish a state-of-the-art research laboratory faculty to support CCRE investigators, research fellows and staff; and 4) To contribute to and take the major lead in the overall development of a long-term program to foster clinical research at University of Hawaii. The situation at the University of Hawaii is unique. Far removed from the mainland USA as a result of its geographic isolation in the Pacific Ocean, the collaborations and affiliations that could naturally develop in a community setting with neighboring Universities are not possible in Hawaii. This CCRE offers the University of Hawaii a realistic opportunity to develop a strong clinical research program that will continue to expand beyond the duration of NIH support, through the recruitment of senior scientists, the successful career development of junior investigators, and the development of strong collaborations and affiliations with the University of Washington and other West Coast institutions. The CCRE will provide the necessary leadership and vision to harness the research investments made by the NIH for the development of the next generation of clinical researchers at the University of Hawaii.