New Photo-Releasable Iron Complexes

该提议涉及铁络合物的开发，该铁络合物在暴露于特定波长的光时崩溃以在被照射的表面释放铁。这些新的化学工具将有助于研究生物过程，这些生物过程被认为是由Fe（III）从正常的螯合状态释放而引起的。这种可光致塌缩的复合物将通过遥控光来精确控制生物系统中释放的Fe（III）的空间、时间和浓度。这些化学工具将专门用于模拟导致血液凝固或血栓形成的过程。Fe（III）被广泛用于在模型中诱导血栓形成，但目前通过将浸在铁溶液中的滤纸放置在研究部位上以非常差的控制方式施用。该提案旨在开发一种更精确的铁给药方法，可以更详细地了解导致血栓形成的机制。血液凝固是健康生物体的重要特征，保护免受脉管系统的损伤，但血栓形成和由此导致的血管闭塞是衰老和许多疾病状态的特征，通常具有致命的后果。导致这一事件的机制是复杂的，是一个重要的研究领域，因为这种理解可能直接关系到健康和福利。Fe（III）通常与其他组织损伤过程（如关节炎）有关，因为它可以催化与氧化应激相关的自由基物质的形成。因此，拟议的化学工具提供的对铁水平的精确控制可能对广泛的研究人员具有吸引力。

This proposal concerns the development of iron complexes that collapse upon exposure to specific wavelengths of light to release iron at the illuminated surface. These novel chemical tools will be useful for studying biological processes believed to arise from the release of Fe (III) from their normal sequestered state. Such photo-collapsible complexes will offer precise control over the space, time and concentration Fe(III) released in a biological system under study by the remote-control of light. These chemical tools will specifically be used to model processes leading to blood coagulation or thrombosis. Fe (III) is widely used to induce thrombosis in models, but is currently administered in a very poorly controlled way by placing filter paper soaked in the iron solution onto the site under study. This proposal seeks to develop a more precise method of administering iron that may provide more detailed understanding of the mechanisms leading to thrombus formation. Blood coagulation is an important feature of the healthy organism, protecting against injury to the vasculature, but the formation of thrombosis and the resulting occlusion of blood vessels is a feature of aging and many disease states, often with fatal consequences. The mechanisms leading to this event are complex and are an important area of study since this understanding may be directly relevant to health and welfare. Fe (III) is often implicated in other tissue damage processes, such as arthritis, because it can catalyse the formation of radical species associated with oxidative stress. The precise control over iron levels offered the proposed chemical tool may therefore be attractive to a wide range of researchers.