HEALTH DISEASE STATUS IN THE BLSA--CLINICAL HEALTH EVALUATION

自1985年以来，BLSA健康评估经历了重大变化，以 完善研究参与者的医疗信息。两个版本 已经实施了健康问卷的一部分。首字母 问卷于1991年3月1日推出，用于参与者的第一次 就诊以确定以前的健康投诉和问题。时间间隔 历史调查问卷于1993年3月1日设立，用于以后的所有 访问记录卫生投诉和卫生状况的变化 并确定症状对日常生活的影响。这个 间隔历史记录提供了参与者对每个问题的先前回答 项，并允许参与者指示更改。间隔史 调查问卷还包括用于以下目的的分支问题的扩展 积极的健康投诉，以及评估这些投诉效果的问题 对日常活动和情绪健康的抱怨。健康 评估还为一些研究提供健康筛查 协议。该股增加了对筛查和 研究方案；为研究人员提供技术支持 开展研究研究；努力最大限度地减少和/或预防 潜在的不良后果或其他问题。作为我们质量的一部分 保证计划我们一直在评估新的价值 用于BLSA研究的健康问卷。 在过去的一年里，我们实施了计时步行，作为迈向 定量的功能评估。该协议是在 过去两年与EDB的Jack Guralnik博士合作。在试行中 对大约100名BLSA参与者进行的研究，步行10和 以正常的速度，以最快的速度，开始增加 60岁左右，当慢性病和功能性残疾时 对我们大多数参与者来说都不是主要问题。这项测试似乎是 对早期病变很敏感，这应该会提供有价值的 了解正常衰老的信息。

Since 1985, the BLSA health evaluation has undergone major changes to improve the medical information about research participants. Two versions of the health questionnaire have been implemented. The initial questionnaire, introduced March 1, 1991, is used on participant's first visit to determine previous health complaints and problems. The interval history questionnaire, instituted March 1, 1993, is used for all subsequent visits to document changes in health complaints and status since their previous visit and to identify the effects of symptoms on daily living. The interval history provides the participant's previous responses to each item and allows the participant to indicate changes. The interval history questionnaire also includes an expansion of branching questions used for positive health complaints with questions assessing effects of these complaints on daily activities and emotional well being. The health evaluation also provides health screening for a number of research protocols. The unit has increased formalized handling of screening and research protocols; provided technical support to investigators in the development of research studies; and worked to minimize and/or prevent potential adverse outcomes or other problems. As part of our quality assurance program we have continued to assess the value of the new health questionnaire for BLSA research. Over the past year, we implemented a timed walk as a first step towards a quantitative functional assessment. The protocol was developed over the past two years in collaboration with Dr. Jack Guralnik, EDB. In a pilot study of about 100 BLSA participants, time required to walk both 10 and 50 feet at a normal pace, and as quickly as possible, begins to increase around 60 years of age, when chronic diseases and functional disability are not major problems in most of our participants. The test appears to be sensitive to early pathological changes, which should offer valuable information in understanding normal aging.