Skyscan 1172 ex-vivo microComputed Tomography System

描述（由申请人提供）：这是一份购买Skyscan 1172离体微计算机断层扫描系统的资金提案，用于支持新泽西州医学和牙科大学/罗伯特伍德约翰逊医学院（UMDNJ/RWJMS）和新泽西州立大学罗格斯大学（Piscataway/New Brunswick）邻近校区的多学科资助研究。近年来，从事骨和生物材料研究的研究人员数量大大增加。临床x射线计算机断层扫描（CT）技术已经适应于通过微CT对更小的物体进行类似的成像，使得研究骨质疏松症和代谢性骨病、癌症转移、影响骨骼的遗传修饰、异位矿化和植入生物材料的小动物模型的重要微结构成为可能。来自UMDNJ/RWJMS、新泽西癌症研究所、新泽西儿童健康研究所和罗格斯大学的14名受资助的教师被确定为离体微ct的主要初始用户。该仪器将成为皮斯卡塔韦罗格斯大学Busch校区药学院的空间共享资源。大学将支持服务合同费用和30%的设施经理工资。此外，两所大学还致力于长期发展一个小动物成像核心设施，其中将包括这个仪器。SkyScan 1172系统是该公司的第二代仪器，包括一个桌面锥束扫描仪，带有微聚焦x射线源，分辨率为5微米，像素尺寸为1至30微米；戴尔双3.6 Ghz奔腾电脑，扇形波束或锥形波束反向投影重建软件。图像处理软件可以在任何基于windows的校园计算机上用于标准的2D和3D骨骼形态分析和动画。相关性：显微ct的非破坏性成像和精确定量使标本可用于随后的组织形态测定，提供比其他方法更完整的表征。获得这些设备将使我们的机构能够从事与人类疾病的病理生理过程和动物模型高度相关的生物医学研究。

DESCRIPTION (provided by applicant): This is a proposal for funds for purchase of a Skyscan 1172 ex-vivo microComputed Tomography system to support multi-disciplinary funded research at the adjacent campuses of the University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School (UMDNJ/RWJMS) and Rutgers, the State University of New Jersey, in Piscataway/New Brunswick. The number of investigators engaged in bone and biomaterials research has greatly increased in recent years. Techniques for clinical x-ray computed tomography (CT) have been adapted for similar imaging of smaller objects by microCT, making it possible to study the important micro-architecture of small animal models of osteoporosis and metabolic bone disease, cancer metastasis, genetic modifications affecting bone, ectopic mineralization, and implanted biomaterials. A group of 14 funded faculty from the UMDNJ/RWJMS, the Cancer Institute of New Jersey, the Child Health Institute of New Jersey, and Rutgers University are identified as major initial users of the ex-vivo microCT. The instrument will be a shared resource in space in the School of Pharmacy, Busch Campus of Rutgers, Piscataway. The Universities will support service contract costs and 30% of the facility manager's salary. In addition, they Universities are committed to the long-range development of a Small Animal Imaging Core Facility, which will include this instrument. The SkyScan 1172 system, the second generation instrument from this company, consists of a desktop Cone-Beam scanner with microfocus x-ray source capable of 5 micron resolution with a pixel size of 1 to 30 microns; Dell dual 3.6 Ghz Pentium computers, reconstruction software for fan-beam or cone-beam back-projection. Image-processing software may be used on any Windows-based campus computer for standard 2D and 3D for bone morphometric analysis and animation. Relevance: The non-destructive imaging and accurate quantification by microCT allows the specimen to be used for subsequent histomorphometry, providing a more complete characterization than otherwise possible. Acquisition of this equipment will enable our institutions to engage in biomedical research highly relevant to pathophysiological processes and animal models of human diseases.