FAMILIAL PSYCHIATRIC DISORDERS & SCHIZOPHRENIA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本项目是一项比较儿童期精神分裂症和注意缺陷多动障碍的家族遗传学研究。本研究的目的是确定与精神分裂症表型的不同方面相关的基因。我们先前的工作证实了早期的报道，即儿童期发作的精神分裂症比成人期发作的精神分裂症更具有家族性，并通过比较精神分裂症表型的三种互补测量的灵敏度和特异性来帮助细化精神分裂症表型的表征：1）精神分裂症的诊断; 2）存在通过临床访谈或问卷调查定义的精神分裂症谱系人格障碍，以及通过注意力/信息处理的某些测量挖掘的3种神经认知障碍。神经认知测量是精神分裂症表型最敏感的指标，而精神分裂症诊断是精神分裂症谱系障碍最特异的指标。此外，我们收集了16名精神分裂症儿童和24名正常对照儿童的MRI使用高分辨率SPGR图像采集协议。我们分析了内侧颞叶体积（杏仁核和前部和后部海马），总颞叶体积和总脑体积，以复制以前的报告中显着减少的内侧颞叶结构的精神分裂症患者。我们将开始收集儿童发病先证者的兄弟姐妹的影像学资料，以检查在先前的研究中证明的精神分裂症患者的结构体积比正常对照组小或大之间的关系，以及上述精神分裂症表型的三种替代测量方法的存在。此外，我们将尝试识别与精神分裂症先证者及其兄弟姐妹大脑中形态学变化相关的基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is a family genetic study comparing childhood onset schizophrenia and attention deficit hyperactivity disorder. The objective of this study is to identify genes associated with different facets of the schizophrenia phenotype. Our prior work corroborated earlier reports that childhood onset schizophrenia is a more familial form of schizophrenia than adult onset schizophrenia and helped to refine the characterization of the schizophrenia phenotype by comparing the sensitivity and specificity of three complimentary measures of the schizophrenia phenotype: 1) a diagnosis of schizophrenia; 2) presence of schizophrenic spectrum personality disorders defined by clinical interview or by questionnaire, and 3 neurocognitive impairments tapped by certain measures of attention/information processing. The neurocognitive measures were the most sensitive index of the schizophrenia phenotype while a diagnosis of schizophrenia was the most specific index of schizophrenia spectrum disorders . In addition, we have collected MRIs from 16 schizophrenic children and 24 normal control children using a high resolution SPGR image acquisition protocol. We have analyzed mesial temporal lobe volumes (amygdala and anterior and posterior hippocampus), total temporal lobe volume and total brain volume in order to replicate prior reports of significant reduction in mesial temporal structures in schizophrenic patients. We will begin to collect imaging data for siblings of child onset probands to examine the relationship between the volume of structures demonstrated in prior research to be either smaller or larger in schizophrenic patients than normal controls, and the presence of the three alternative measures of the schizophrenia phenotype cited above. In addition, we will attempt to identify genes associated with the presence of morphometric changes in the brains of schizophrenic probands and their siblings.