Multidisciplinary Psychiatry Genetics Training Program

描述(由申请人提供)：本申请的中心目标是在行为学、神经科学和遗传学方面产生创新的生物医学研究，精神病学、人类遗传学、神经生物学、统计学和心理学。这一培训计划自2002年开始以来，一直专注于复杂遗传精神疾病遗传学的跨学科方法，包括基础研究和技术开发，每年有两个博士后时段。现有的研究优势包括双相情感障碍和精神分裂症的分子遗传学研究，行为障碍转基因小鼠模型和治疗的开发，DNA序列和单倍型图谱的生物信息学，复杂表型遗传分析方法的开发，遗传变异的进化和流行病学分析，以及临床研究的微阵列方法。该培训计划位于鼓励跨学科研究合作的环境中。现已确定并招募了两类受训人员：1)行为保健专业人员(医学博士或其他博士学位)，具有从事相关临床或基础研究的潜力，如家族学、遗传流行病学和临床转化研究；2)适当基础和应用科学领域的博士(或医学博士/博士)，包括人口遗传学、分子和细胞神经生物学、认知和系统神经科学、遗传流行病学和生理心理学。我们很幸运地用优秀的研究员填补了所有空缺；三名行为健康护理专业人员和一名基础/翻译博士已经完成了我们的项目。此外，参加了我们的学分教学调查课程的博士生和医学博士/博士生将为未来几年提供招聘机会。对于每个受训人员，该计划包括正式课程学习、由计划教员举办的一系列研讨会、在计划开始时适当时在几个实验室轮换，以及在他们选择的实验室进行强化指导培训。在适当的时候提供双重临床/基本指导。所有研究员都参加了大学临床研究培训计划的入门课程，并参加了神经生物学委员会和精神病学、统计学、健康研究、心理学和人类遗传学系提供的适当研究生课程。为了促进研究员和导师之间的互动，学员们每年都会举办研讨会，并有机会在一年一度的芝加哥大学神经科学日上展示他们的成就。根据该计划在最初培训期间取得的成功，我们要求延长T32赠款，将每年的奖学金名额从两个增加到三个。

DESCRIPTION (provided by applicant): The central goal of the Departments in this application, Psychiatry, Human Genetics, Neurobiology, Statistics, and Psychology, is generating innovative biomedical research in behavior, the neurosciences, and genetics. This training program has focused on interdisciplinary approaches to genetics of complex inheritance psychiatric disease, including basic research and technology development, since its inception in 2002, with two postdoctoral slots per year. Existing research strengths include molecular genetic research into bipolar illness and schizophrenia, development of transgenic murine models of behavioral disorders and treatment, bioinformatics of DNA sequence and haplotype maps, development of methods for genetic analysis of complex phenotypes, evolutionary and epidemiologic analysis of genetic variation, and microarray methods in clinical investigation. The training program is situated in an environment which encourages interdisciplinary research collaborations. Two types of trainees have been identified and recruited: 1) behavioral health care professionals (MDs or other doctoral degree) with demonstrated potential for a career in pertinent clinical or basic research, such as family studies, genetic epidemiology, and clinical translational research; and 2) PhDs (or MD/PhDs) from appropriate basic and applied science fields, including population genetics molecular and cellular neurobiology, cognitive and systems neuroscience, genetic epidemiology, and physiological psychology. We have been fortunate to fill all available slots with excellent Fellows; three behavioral health care professionals and one basic/translational PhD have completed our program. Additionally, PhD and MD/PhD students who have taken our didactic survey course for credit offer recruitment opportunities for future years. For each trainee, this program includes formal course studies, a series of seminars given by the program faculty, rotation in several laboratories if appropriate at the beginning of the program, and intensive mentored training in their chosen laboratory. Dual clinic/basic mentorship is offered when appropriate. All fellows take the introductory course of the University Clinical Research Training Program, and participate in appropriate graduate courses offered by the Committee on Neurobiology, and the Departments of Psychiatry, Statistics, Health Studies, Psychology and Human Genetics. To foster interactions among the fellows and mentors, trainees give annual seminars and have an opportunity to present their accomplishments at the annual University of Chicago Neuroscience Day. Based on the successes of this program during its initial training period, we request renewal of the T32 grant with increase of the number of Fellowship slots per year from two to three.