Identification of Chemopreventive Agents Against Lung Tumorigenesis

描述(由申请人提供)： 肺癌是癌症死亡的主要原因。美国每年有15万人死亡，约16万新确诊病例。死亡率和新病例的可比性表明，几乎所有的肺癌患者都会死于这种疾病。即使是认真的说，在过去的几十年里，肺癌的治疗也没有太大的改善：肺癌患者的5年存活率只从20世纪70年代的7%增加到目前的15%。肺癌的糟糕治疗有力地证明了预防肺癌的发生是控制这种疾病的有效方法。根据文献报道，卡瓦提取物是一种潜在的预防肺癌发生的饮食。本研究的目的是在有效的肺肿瘤形成动物模型中建立卡瓦提取物的化学预防活性，并从卡瓦提取物中鉴定出真正的化学预防药物(S)。为了实现这一目标，我们计划使用A/J小鼠模型来评估从卡瓦提取物中获得的七个候选化合物的化学预防活性，这些候选物质是通过有机合成或卡瓦提取物的分级获得的。

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer death. There are 150,000 mortalities and around 160,000 new cases diagnosed in USA each year. The comparable rates of mortalities and new cases suggest that almost all of the lung cancer patients would die through this disease. Even seriously, there is not much improvement in lung cancer treatment over the past decades: the 5-year lung patient survival rate only increases from 7% of the 1970s to the current 15%. The poor treatment of lung cancer argues strongly for the prevention of lung tumorigenesis as an effective approach to control this disease. Based on the literature reports, kava extract is one potential diet to prevent lung tumorigenesis. The goal of this study is to establish the chemoprevention activity of kava extract in a valid lung tumorigenesis animal model and to identify the actual chemopreventive agent(s) from kava extract. To accomplish this goal, we plan to use an A/J mouse model to evaluate seven candidates from kava extract, obtained through either organic synthesis or fractionation of kava extract, for their chemopreventive activities.