Exploitation of Advanced Photonic Boisensors(EAPho-Bio- A new tool for fast and untrasensitive detection of biochemical and biomolecular interactions

该计划计划开展一项新的研究，开发一种新型的光子生物传感器，用于快速、灵敏和实时地检测非常小的生化样品，并对蛋白质/蛋白质、蛋白质/DNA和细胞相互作用进行动态分析。光子生物传感器将利用特殊纤维中的紫外光和飞秒刻字微结构开发，通过刻字后处理增敏，并使用生物活性亲和技术进行生物活性激活。预计高生物灵敏度/选择性光学传感器在基因组学、蛋白质组学和药物发现研究与开发以及环境监测中将具有潜在的应用。拟议的计划旨在通过由阿斯顿大学光子学研究组和分子生物科学研究组合作开展这一项目，使光子学技术与生命科学应用之间形成强大的互动。

This programme proposes to carry out novel research on the exploitation of a new class of photonic biosensors for fast, sensitive and real-time detection of very small biochemical samples and the dynamic analysis of protein/protein, protein/DNA and cellular interactions. The photonic biosensors will be developed using UV and femtosecond inscribed microstructures in speciality fibres, sensitised by post-inscription processing and bioactivated using bioactive affinity techniques. It is envisaged that, when developed, the highly bio-sensitive/selective optical sensors will have potential applications in genomics, proteomics and drug discovery research and development, as well as in environmental monitoring.The proposed programme intends making to form a strong interaction between the photonics technology and lifescience applications by carrying out this project collaboratively between the Photonics Research Group and Molecular Bioscience Research Group at Aston University.L. Beneficiaries