Lipid Transport-Connecting Fundamental Membrane Assembly To Human Disease

描述（由申请人提供）：摘要概述：本申请是为了支持第一次国际会议，该会议仅关注细胞脂质转运及其与人类遗传疾病的关系。会议将为这一学科的最新研究提供一个论坛，由于生物化学，遗传学和基因组学在多种真核生物中脂质转运的进展，这一学科正在迅速扩大。会议将于2008年10月29日至11月2日在加拿大AB省的坎莫尔举行。与会者将是主要的科学家，他们的重点是细胞内的脂质转运过程，以及这些过程与细胞病理学和人类疾病的关系。除了受邀演讲者外，与会者还将包括在会议主题领域开展积极研究项目的资深科学家，以及来自这些实验室的研究生和博士后研究员。鼓励妇女和少数民族科学家参加这次会议，25%的受邀发言者是妇女。在海报会议期间，将有足够的机会由未被邀请发言的与会者介绍工作，并进行简短的口头介绍，这与邀请发言者的介绍相结合。会议的目的是宣传细胞脂质转运的最新进展，并批判性地讨论疾病过程如何导致分子缺陷。主要内容包括：1）ABC转运蛋白及其在人类和小鼠眼、肺和肝脏疾病中的作用，以及原核生物内毒素的生物合成; 2）P型ATP酶及其在真核生物膜组装过程中的作用，以及人类肝内胆汁淤积的发生; 3）脂质识别蛋白在细胞生长发育和甾体激素产生中的重要性;和4）Niemann Pick C家族蛋白在控制肠和脑中脂质转运过程中的作用及其与特定疾病过程的关系。7.项目叙述N/A

DESCRIPTION (provided by applicant): Abstract Summary: This application is for support of the first international meeting focused solely upon the topic of cellular lipid transport and its relationship to human genetic diseases. The meeting will provide a forum for the latest research in this discipline, which is now rapidly expanding as a consequence of advances in the biochemistry, genetics and genomics of lipid transport in multiple eukaryotes. The meeting will convene from Oct 29-Nov 2, 2008; in Canmore, AB, Canada. The participants in the meeting will be leading scientists whose focus is upon lipid transport processes within cells, and the relationship of these processes to cellular pathology and human diseases. In addition to invited speakers, attendees will include senior scientists with active research programs in the topic areas of the conference, and graduate students and postdoctoral fellows from these laboratories. Women and minority scientists are encouraged to participate in this meeting and 25% of the invited speakers are women. There will be ample opportunities for presentation of work by attendees who are not invited speakers, during poster sessions, and short oral presentations, which are mixed with invited speaker presentations. The objectives of the meeting are to publicize the latest advances in the topics of cellular lipid transport and critically discuss how disease processes result from molecular defects. The topics to be addressed include: 1) ABC transporters and their roles in eye, lung and liver disease in humans and mice, and the biosynthesis of endotoxins in prokaryotes; 2) P-type ATPases and their role in fundamental membrane assembly processes of eukaryotes, and the development of intrahepatic cholestasis in humans; 3) the importance of lipid recognition proteins in cell growth and development and production of steroid hormones; and 4) the role of Niemann Pick C family proteins in controlling lipid transport processes in the intestine and brain and their relationship to specific disease processes. 7. Project Narrative N/A