Veterinary Comparative Respiratory Society 2008 Symposium

描述（由申请人提供）： 动物模型的生物医学使用继续提供对哺乳动物呼吸道的生理学和病理生理学的有价值的见解，并且各种动物模型在理解和治疗人类呼吸道疾病方面提供了关键进展。实验室啮齿动物是人类生物医学研究中使用的最大比例的动物，其价值来自其经济以及研究人员操纵这些动物的基因组以确定特定基因或基因产物的作用的能力。与此同时，家养动物如狗、猫、马和牲畜的价值越来越受到生物医学研究界的重视，因为它们在生理和目的论上与人类相似，并且自然发生的疾病与重要的人类疾病相似。因此，这些大型动物模型在转化研究中的价值是无与伦比的。然而，由于在人类生物医学研究中使用这些模型的成本和困难，它们作为研究工具未得到充分利用。该计划的目的是在其相对于实验室啮齿动物模型以及相关人群的优势和劣势的背景下，介绍有关人类呼吸道疾病的更常见和更好表征的家养动物模型的当前数据。演讲者将根据他们使用这些模型作为以人为本的生物医学研究的基本和/或翻译工具的第一手经验进行选择。该计划将结束与可能的策略，使这些模型更容易获得生物医学界的关键讨论，和生物医学研究资金更容易获得那些寻求使用这些模型的生物医学知识的进步的调查人员。研讨会将由兽医比较呼吸学会共同主办，该科学组织有25年的历史，每年举办关于家畜呼吸生理学和病理生理学的国际科学会议。会议将强调机构间合作的发展和年轻研究人员融入生物医学科学界。 了解复杂的人类疾病以及开发和测试合适的治疗方法需要使用这些疾病的复杂动物模型。这些模型通常是家养动物，如狗、猫、马和牛，其中自然发生类似的疾病。本次研讨会将审查这些模型的现有知识和实际挑战，以使它们更容易获得生物医学研究界。

DESCRIPTION (provided by applicant): Biomedical use of animal models continues to provide valuable insights into the physiology and pathophysiology of the mammalian respiratory tract, and various animal models have provided key advances in the understanding and treatment of human respiratory disease. Laboratory rodents represent the largest proportion of animals used in human biomedical research, with their value arising both from their economy as well as from the ability of researchers to manipulate the genome of these animals to identify the role of specific genes or gene products. At the same time, the value of domestic animals such as dogs, cats, horses, and livestock is increasingly appreciated by the biomedical research community due to their physiological and teleological similarity to humans, as well as the natural occurrence of diseases analogous to important human diseases. Thus, these large animal models are unmatched for their value in translational research. However, due to the cost and difficulty of employing these models in human biomedical research, they are underutilized as research tools. The purpose of this program is to present the current data regarding the more common and well-characterized domestic animal models of human respiratory disease in the context of their strengths and weaknesses relative to laboratory rodent models as well as the relevant human population. Speakers will be selected based on their first-hand experience in using these models as basic and/or translational tools for human-oriented biomedical research. The program will conclude with a critical discussion on the possible strategies for making these models more accessible to the biomedical community, and biomedical research funding more accessible to those investigators seeking to use these models for the advancement of biomedical knowledge. The symposium will be co-sponsored by the Veterinary Comparative Respiratory Society, a scientific organization with a 25 year history of holding annual international scientific conferences on respiratory physiology and pathophysiology of domestic animals. The conference will emphasize the development of interinstitutional collaborations and the integration of young investigators into the biomedical science community. Understanding complex human disease and the development and testing of suitable treatments requires the use of complex animal models of those diseases. Such models are typically domestic animals such as dogs, cats, horses, and cattle, in which similar diseases occur naturally. This symposium will review the current knowledge and practical challenges of these models in order to make them more accessible to the biomedical research community.