2008 Single Molecule Approaches to Biology Gordon Research Conference

描述(由申请人提供)：本提案请求部分支持将于2008年8月12-17日在新罕布夏州新伦敦的科尔比-索耶学院举行的单分子生物学方法国际会议，作为戈登研究会议系列的一部分。单分子方法避免整体平均并捕捉瞬时中间体和异质行为的能力，使它们在阐明分子机制的机制方面特别强大：它们做什么，它们如何单独工作，它们如何协同工作，以及最后，它们如何在活细胞内工作。本次会议旨在让分子和细胞生物学领域的顶尖专家与单分子测量和操作领域的创新者汇聚一堂。其目的是更好地促进单分子方法的使用，以产生新的生物学知识，并更好地指导单分子技术的开发和实施，以解决紧迫的生物学问题。这次会议的具体目标将是召集50位代表单分子研究新领域的演讲者，总共170人，在相对孤立的环境中举行为期五天的会议。该计划将有九个环节，涵盖光学探针、高分辨率仪器、活细胞分析和理论进步方面的尖端技术发展，以及在RNA科学、染色质生物学、DNA复制/重组/修复、细胞骨架马达、基因表达及其调控方面令人兴奋的新应用。此外，四个下午的海报环节让与会者有机会积极参与科学话语。这一应用的意义在于，戈登生物学单分子方法研究会议是促进和加强新兴技术和创新方法交流的独特工具，这些技术和创新方法应用于各种生物学问题。这一应用与健康相关的是，单分子方法提供了以前无法获得的关于所有形式的生命(包括人类和人类病原体)必不可少的基本生化过程的数据，使讨论更加尖锐，并产生了新的观点。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Single Molecule Approaches to Biology as part of the Gordon Research Conference series to be held in Colby-Sawyer College, New London, New Hampshire, August 12-17, 2008. The ability of single molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of molecular machineries: what they do, how they work individually, how they work together, and finally, how they work inside live cells. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules. The intention is to better promote the use of the single-molecule approach to generate new biological knowledge and to better orient the development and implementation of single molecule techniques for compelling biological problems. The specific aims of this meeting will be to convene 50 speakers that represent new emerging areas of single molecule research with a total of 170 participants for a five day conference in a relatively isolated setting. The program will have nine sessions that cover cutting-edge technical developments in optical probe, high resolution instruments, live cell analysis, and theoretical advancement as well as exciting new applications to RNA science, chromatin biology, DNA replication/recombination/repair, cytoskeleton motors, gene expression and its regulation. In addition, four afternoon poster sessions give attendants opportunities to actively participate in the scientific discourse. The significance of this application is that the Gordon Research Conference on Single Molecule Approaches to Biology is a unique vehicle to promote and enhance the exchange of emerging technologies and innovative methods of applying them to various biological problems. The health relatedness of this application is that the single molecule approaches provide previously unobtainable data on fundamental biochemical processes that are essential for all forms of life, including human and human pathogens, sharpening the discussion and generating new viewpoints.