FASEB Summer Conference on Protein Phosphatases

描述（由申请人提供）：蛋白质磷酸化的翻译后修饰可能是最常见的生物调控机制，蛋白质磷酸酶是控制这一过程的关键和复杂酶。本申请要求持续支持第十届和随后的FASEB蛋白磷酸酶夏季研究会议，也承认蛋白酪氨酸磷酸酶鉴定20周年。这个两年一次的会议，是该主题的主要北美会议，为实验生物学家探索和讨论蛋白质磷酸酶及其在生命调节中的重要作用的当前研究前沿领域提供了一个亲密的环境。会议将重点介绍磷酸酶在癌症、干细胞、糖尿病和代谢紊乱中作用的重大进展。我们的会议将包括关于癌症、糖尿病、神经系统疾病、传染病和发育异常的会议，这些都是蛋白磷酸酶发挥关键作用的领域。

DESCRIPTION (provided by applicant): Post-translational modification by protein phosphorylation is perhaps the most common biological regulatory mechanism, and protein phosphatases are key and complex enzymes that control this process. This application requests ongoing support for the Tenth and subsequent FASEB Summer Research Conferences on Protein Phosphatases, also recognizing the 20th anniversary of the identification of protein tyrosine phosphatases. This bi-annual meeting, the major North American meeting on this topic, provides an intimate environment for experimental biologists to explore and discuss cutting edge areas of current research on protein phosphatases and their important role in regulation of life. Major advances in the role of phosphatases in cancer, stem cells, diabetes, and metabolic disorders will be highlighted at the meeting. Our conference will include sessions on cancer, diabetes, neurological disorders, infectious diseases and developmental abnormalities, all areas where protein phosphatases play critical roles. The Specific Aims of the conference are: (1) To present the most current work on the structure, regulation and function of the protein phosphatases. Particular attention will be paid to the diverse physiological and pathophysiological roles of these enzymes, as elucidated by the use of diverse approaches in mammalian and other eukaryotic systems. (2) To highlight major achievements and emerging opportunities in the field through the use of Opening and Keynote Lectures, respectively. (3) To encourage the recruitment and development of new and young scientists in the field, especially junior faculty, women and under-represented minorities, by selecting a significant number of speakers from the submitted abstracts and inviting contributions from those making novel advances in the field.