RNA and the Etiology of Disease

描述(由申请者提供)：申请部分资助EMBO赞助的关于RNA和疾病病因学的研讨会。这次会议的主要目标是帮助促进科学交流和促进对被广泛认为是影响人类疾病的关键分子成分之一--即RNA--的进一步研究。当剪接、输出、稳定、定位或翻译等几个RNA加工步骤中的任何一个出错时，都可能导致癌症、神经变性、强直性肌营养不良、脆性X和许多其他疾病。此外，现在已知miRNAs和其他小RNA可以深刻影响癌症、代谢紊乱和病毒感染等疾病。在更大的层面上，研究人类疾病，特别是与RNA分子生物学有关的疾病，除了检查人体组织外，还必须包括动物模型，如小鼠、果蝇、非洲爪哇、线虫和培养细胞等。因此，本次会议寻求将RNA作为共同的线索，不仅通过人类细胞和组织，而且也通过动物和细胞培养模型来研究人类疾病。这次会议将吸引各种各样的研究人员，他们在研究各种疾病的同时，对确定RNA如何控制调节疾病状态的基本过程有共同的兴趣。会议主题将强调RNA和人类疾病的起源，并将包括RNA剪接、翻译、破坏、运输，当然还有miRNAs和其他小RNAs的学生。这次会议的方法是跨学科的，这对抗击人类疾病至关重要。

DESCRIPTION (provided by applicant): Partial support is requested for an EMBO-sponsored workshop on RNA and the Etiology of Disease. The major goals of this meeting are to help foster scientific exchange and stimulate further investigation into what is widely regarded as one of critical molecular components influencing human disease; namely RNA. When any one of several RNA processing steps such as splicing, export, stability, localization, or translation goes awry, diseases such as cancer, neural degeneration, myotonic dystrophy, Fragile-X, and many others can result. In addition, miRNAs and other small RNAs are now known to profoundly influence such maladies as cancer, metabolic disorders, and viral infection. On a larger level, the study of human disease, particularly as it relates to RNA molecular biology must include animal models such as mice, Drosophila, Xenopus, C. elegans, and cultured cells, among others, in addition to the examination of human tissue. Thus, this meeting seeks to use RNA as the common thread to examine human disease not through human cells and tissues exclusively, but through animal and cell culture models as well. The meeting will attract a wide variety of investigators who, while working on various diseases, have the common of interest of determining how RNA controls basic processes that mediate the disease state. The meeting theme will emphasize RNA and the origin of human disease, and will include students of RNA splicing, translation, destruction, transport, and of course miRNAs and other small RNAs. The meeting is cross-disciplinary in its approach, which is essential for combating human disease.