Interdisciplinary Training in Quantitative Cell Biology

描述（由申请人提供）：目前的申请是在NIH路线图倡议下资助的奖项的竞争性更新，该倡议预示着2004年海洋生物实验室（MBL）生理学课程新时代的开始。这门新课程的使命是提供细胞生理学的跨学科培训，预测我们认为在未来20年将是重要的未来发展。我们和其他许多人看到了未来在细胞生理学的定量分析和计算建模方面的关键挑战。MBL生理学课程将提供独特的跨学科培训环境和研究计划，以迎接这一挑战。这是我们的愿景，该课程将汇集生物和物理/计算科学家，无论是在教师和学生的身体一起学习和工作在细胞生理学目前令人兴奋的问题。课程设计包括三个线程：细胞运动;细胞分裂和信号伴随着计算分析，将跨越三个2周的会议。这些会议将促进通过实践学习，特别强调激发实验创造力和跨学科方法。该课程的共同主任罗恩瓦尔和蒂姆米奇森是具有良好培训记录的领先细胞生物学家。他们聚集了一支优秀的教师队伍，其中包括具有细胞生理学，物理学，工程学和计算科学背景的教师。此外，共同主任还增加了一批杰出的访问学者和MBL科学界成员，以提供额外的培训。我们将继续努力使本课程成为公认的跨学科培训场所，实验和物理/计算科学家聚集在一起，教授他人他们的哲学和方法。在这个应用程序中，我们请求支持继续这一令人兴奋的奋进。生物学的重大进展往往是通过学科之间的合作取得的。这可以并且已经导致对正常细胞功能的细节的理解，以及这在疾病中是如何出错的。希望这也将导致新的疗法和治疗。自1899年以来，每年在马萨诸塞州伍兹霍尔的海洋生物实验室提供的生理学课程在生物学和物理学之间的跨学科环境中提供高级研究生水平的培训。学生在密集的讲座实验室环境中学习：生物学家学习如何使用计算机建模，物理学家学习显微镜和其他生物学工具。根据我们过去的经验，我们知道，未来的学生从这门课程将作出重大贡献，我们的基本细胞过程的理解。该提案要求继续支持伍兹霍尔的生理学课程。

DESCRIPTION (provided by applicant): The current application is the competing renewal of an award funded under the NIH Roadmap Initiative, which heralded the beginning of a new era for the Physiology Course at the Marine Biological Laboratory (MBL) in 2004. The mission of this newly focused course is to provide interdisciplinary training in cell physiology, anticipating future developments that we believe will be important in the next 20 years. We, and many others, see a key challenge for the future in quantitative analysis and computational modeling of cell physiology. The MBL Physiology Course will provide a unique interdisciplinary training environment and research program to meet this challenge. It is our vision that the Course will bring together biological and physical/computational scientists, both in the faculty and student body to study and work together on current exciting problems in cell physiology. The Course design consists of three threads: cell motility; cell division and signaling accompanied by computational analysis that will span three 2-week sessions. These sessions will promote learning by practice with a particular emphasis on stimulating experimental creativity and interdisciplinary approaches. The co-directors for the Course, Ron Vale and Tim Mitchison, are leading cell biologists with strong training records. They have assembled an outstanding faculty, which includes teachers with backgrounds in cellular physiology, physics, engineering and computational science. In addition, the co-directors have added a group of distinguished visiting scholars and members of the MBL scientific community to provide additional training. We will continue to strive to make this Course a recognized venue for interdisciplinary training where experimental and physical/computational scientists gather to teach others their philosophies and approaches. In this application we request support for continuation of this exciting endeavor. Significant advances in biology are often made through collaborations at the interface between disciplines. This can and has lead to an understanding in details of normal cellular function and how this can go awry in disease. Hopefully this will also lead to new therapies and cures. The Physiology Course offered annually at the Marine Biological Laboratory in Woods Hole, MA since 1899 provides advanced graduate level training in an interdisciplinary environment at the interface between biology and physics. Students learn in an intensive lecture-laboratory setting: biologists are taught how to use computer modeling and physicists are taught microscopy and other tools of biology. Based on our past experience we know that future students from this Course will make significant contributions to our understanding of basic cellular processes. This proposal requests continuation of support for the Physiology Course in Woods Hole.