Spectro-temporal and binaural response properties

描述（申请人提供）：下丘中央核（ICC）在光谱、时间和双耳信息的声学分析中起着关键作用。它的层流组织和高度有序的聚合传入事件表明，在向听觉丘脑过渡的过程中，巩固这些声学信息发挥了关键作用。我们假设，颞光谱和双耳感受野特征的分布布局将在中央核中系统地排序，以反映神经支配传入事件和局部collle电路的模式。在这项研究中，我们提出表征中央核内光谱-颞感受野（STRF）偏好的分布组织。具有结构化宽带噪声的STRF分析将用于表征神经元偏好，并将其与传统纯音刺激的测量系统地联系起来。提出了单单元记录实验，以表征STRF偏好的微观组织，并确定接收野遗传/构建在脑干向中央核转变中的作用。然后，ICC的分布式映射将使我们能够同时表征三维结构中光谱、时间和双耳接受野偏好的全球组织。同时解剖研究将显示两条平行记录轨迹的地形位置以及它们各自到内侧膝状体的投影。预期的研究结果将为理解复杂听觉刺激下的光谱-时间和双耳特征的声学分析提供一个框架，然后我们可以将其与脑干输入、局部电路和模块化组织的组织层次联系起来。

DESCRIPTION (provided by applicant): The central nucleus of the inferior colliculus (ICC) plays a key role in the acoustic analysis of spectral, temporal and binaural information. Its laminar organization and highly ordered mosaic of converging afferents suggests a critical role in consolidating this acoustic information in the transition to the auditory thalamus. We hypothesize that the distributed layout of spectro-temporal and binaural receptive field features will be systematically ordered in the central nucleus in a manner that reflects the patterns of innervating afferents and the local collicular circuitry. In this study, we propose to characterize the distributed organization of spectro-temporal receptive field (STRF) preferences within the central nucleus. STRF analysis with structured broadband noise will be used to characterize neuronal preferences and to systematically relate these to measurements from conventional pure-tone stimuli. Single unit recording experiments are proposed to characterize the micro-organization of STRF preferences and to identify the roles of receptive field inheritance / construction in the transformation from the brainstem to the central nucleus. Distributed mapping of the ICC will then allow us to simultaneously characterize the global-organization of spectral, temporal and binaural receptive field preferences within the three dimensional structure. Concurrent anatomic studies will show the topographic position of two parallel recording tracks and their respective projections to medial geniculate body. The expected findings will provide a framework for understanding the acoustic analysis of spectro-temporal and binaural features in complex auditory stimuli, which we can then relate to the organizational hierarchy of brainstem inputs, local circuitry, and modular organization.