Host-pathogen interactions in clostridial myonecrosis

我们将从宿主和病原体的角度分析导致气体坏疽的细菌与受感染宿主之间的相互作用。我们将研究如何调节宿主对感染的反应，以降低疾病的严重性，并确定宿主中细菌生长所必需的生化过程，这是疾病的必要先决条件。结果将是更好地理解疾病病因的机制，并改善疾病控制。

We will analyse the interaction between the bacteria that cause gas gangrene, and the infected host, from both a host and pathogen perspective. We will examine how the host’s response to infection can be modulated to decrease the severity of disease and we will identify the biochemical processes that are essential for bacterial growth in the host, a necessary prerequisite for disease. Outcomes will be a better understanding of the mechanisms of disease causation and improved disease control.