Training in Molecular Physics of Biological Systems

描述（由申请人提供）：项目概要：康奈尔大学的分子生物物理学培训资助计划提供了结合物理和生物科学的跨学科培训。被选中参加的受训人员可能具有物理或生物科学的本科学位，并且必须被康奈尔大学研究生院录取，接受博士学位的培训。在25个参与教师的研究生领域之一，包括：物理学，应用物理学，化学和化学生物学，生物化学，分子和细胞生物学，计算科学，神经生物学和行为学，营养学，药理学和生物物理学。 该方案旨在每年支持12名受训人员，每个人的总支持时间为2-3年。 受训人员进行跨学科的研究，在数学，量子力学，统计热力学，生物化学和分子生物学，计算和仪器，以及其他专题的高级课程。 论文研究和参与教师实验室的合作完成了分子生物物理学教学和跨学科研究职业生涯的准备。 参与的教职员工与康奈尔大学的完善和不断发展的生物物理学计划，提供了这个培训计划的重点。分子生物物理学的研究机会包括使用理论方法研究蛋白质和其他大分子的结构和功能，通过同步加速器X射线晶体学，电子自旋共振光谱学和多维NMR确定结构;分子马达的研究;细胞膜，受体和神经递质的结构和分子机制以及相关的细胞功能;材料和技术的发展，包括非线性激光显微镜，稳态和时间分辨光谱和成像;单通道记录;光镊;纳米纤维;并通过合作和中心设施，上述的许多组合。 计算机能力，网络化，在线和最终在康奈尔理论中心扩展了分子生物物理学研究和教育设施的阵列。 康奈尔大学为成功和富有成效的分子生物物理学培训补助金的持续增长提供了理想的基础设施。 相关性：受训人员将参加的所有项目都旨在解决对公共卫生具有重要意义的生物医学问题。 特别是，该计划的目标是培养学生将物理和化学的强大技术应用于医学相关问题。 这将导致设计新的药物疗法，确定新的细胞和分子靶点的药物治疗，更好地了解参与疾病的细胞成分，以及新的诊断程序（特别是非侵入性程序）。

DESCRIPTION (provided by applicant): Project summary: Cornell's Molecular Biophysics Training Grant Program offers vigorous interdisciplinary training that combines physical and biological sciences. The trainees selected to participate may have undergraduate degrees in either physical or biological sciences and must have been admitted to the Graduate School at Cornell for training leading to the Ph.D. in one of the Graduate Fields of the twenty-five participating faculty including: Physics, Applied Physics, Chemistry and Chemical Biology, Biochemistry, Molecular and Cell Biology, Computing Science, Neurobiology and Behavior, Nutrition, Pharmacology and Biophysics. The program is designed to support 12 trainees each year, with a total duration of support for each individual at 2-3 years. Trainees undertake interdisciplinary studies with advanced courses in mathematics, quantum mechanics, statistical thermodynamics, biochemistry and molecular biology, computation and instrumentation, and other special topics. Thesis research and collaborations in the laboratories of the participating faculty complete preparation for a career of teaching and interdisciplinary research in molecular biophysics. The participating faculty members are associated with Cornell's well established and continuously growing Biophysics Program which provides the focus for this training program. Research opportunities in molecular biophysics include investigation of structure and function of proteins and other macromolecules using theoretical approaches, structure determination by synchrotron X-ray crystallography, electron spin resonance spectroscopy, and multidimensional NMR; studies of molecular motors; structures and molecular mechanisms of cell membranes, receptors, and neurotransmitters and associated cellular functions; materials and technology developments including nonlinear laser microscopy, steady-state and time resolved spectroscopy and imaging; single channel recording; optical tweezers; nanofabrication; and through collaborations and Center facilities, many combinations of the above. Computer capabilities, networked, on-line and culminating in the Cornell Theory Center extend the array of facilities for research and education in molecular biophysics. Cornell provides the ideal infrastructure for continued growth of the successful and productive Molecular Biophysics Training Grant. Relevance: All of the projects in which trainees will participate are designed to address biomedical problems of importance to public health. In particular, the goal of this program is to train students to apply the powerful techniques of physics and chemistry to problems of medical relevance. This will lead to the design of new drug therapies, the identification of new cellular and molecular targets for drug therapy, a better understanding of the cell components involved in diseases, and new diagnostic procedures (particularly, noninvasive procedures).