Integrated Training in Reproductive Sciences

描述（由申请人提供）：本培训计划的目的是准备生殖内分泌医生和其他科学家在生殖生物学的职业生涯在基础科学或临床部门。该培训计划已运作了20年，在此期间，82名博士后学员（53名医学博士，29博士）有27名研究生接受了培训。该计划是多方面的，基础广泛，整合分子内分泌学，细胞生物学，细胞信号传导，遗传学和生理学。研究培训将由生殖科学中心（CRS）的15名成员提供，他们在基础科学和临床部门的医学院担任教职。直接负责研究培训的经验丰富的计划教师拥有广泛的科学专业知识和兴趣。目前的研究项目涉及生殖生物学的重要问题，包括：类固醇激素受体作用的机制;类固醇和神经类固醇激素生物合成和作用的分子遗传学和调节;生殖道的发育; GnRH神经元搏动的机制;子宫内膜和胎盘功能的调节;男性和女性不育的遗传学;胎儿肾上腺生长，发育和分化;性别决定;正常和异常生殖功能的内分泌调节。受训人员由指导委员会在正式申请CRS后选择，在博士生的情况下，选择适当的研究生课程。研究生攻读博士学位的课程。生物医学科学或生物科学专业学位。将为博士提供博士后培训。相关学科的候选人，以及经过临床培训的科学家，学位和先前的专业培训。除了规定的课程工作和实验室或临床研究，学员将参加一系列定期安排的课程，研讨会，期刊俱乐部，会议和研讨会的负责任的研究行为。学员学习设计和执行基础研究项目，分析数据，并为著名的同行评审期刊撰写手稿。受训人员还准备和提交校外资助的赠款申请，进一步为独立的学术生涯做好准备。该计划的优势包括：1）教师的多样技能和兴趣2）教师的互动3）教师的大量实验室资源4）在UCSF生殖，内分泌学，细胞生物学，遗传学和相关领域的研究环境。

DESCRIPTION (provided by applicant): The objective of this Training Program is to prepare reproductive endocrine physicians and other scientists for careers in reproductive biology in basic science or clinical departments. The training program has been operative for the past 20 years during which time 82 postdoctoral trainees (53 M.D., 29 Ph.D.) and 27 graduate students have received training. The program is multifaceted and broadly based, integrating molecular endocrinology, cell biology, cell signaling, genetics, and physiology. Research training will be provided by the 15 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in the School of Medicine in both basic science and clinical departments. The experienced Program Faculty members who are directly responsible for the research training have a broad range of scientific expertise and interests. Current research programs address important issues in reproductive biology including: mechanism of steroid hormone receptor action; molecular genetics and regulation of steroid and neurosteroid hormone biosynthesis and action; development of the reproductive tract; mechanism of GnRH neuronal pulsatility; regulation of endometrial and placental function; genetics of male and female infertility; fetal adrenal growth, development and differentiation; sex determination; endocrine regulation of normal and abnormal reproductive function. Trainees are selected by a Steering Committee following formal application to the CRS and, in the case of predoctoral students, to an appropriate graduate program. Graduate students pursue a course of study leading to the Ph.D. degree in Biomedical Sciences or Program in Biological Sciences. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and also to clinically trained scientists with M.D. degrees and prior specialty training. In addition to prescribed course work and laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees also prepare and submit grant applications for extra-mural funding, preparing them further for independent academic careers. The strengths of the program include: 1) diverse skills and interests of the faculty 2) the interactiveness of the faculty 3) the substantial laboratory resources of the faculty 4) the outstanding environment for research in reproduction, endocrinology, cell biology, genetics and related areas at UCSF.