Basic Sciences Training in Urology

描述（由申请人提供）： 本培训计划旨在招募和培训医学博士、医学博士/博士，或在华盛顿大学（UW）临床和研究环境中与泌尿生殖系统（GU）疾病相关研究的博士。医学博士将从我们的泌尿外科住院医师中招募，然后再进行PG 4研究年和/或完成临床住院医师培训的医学博士。重点将放在招募潜在的医生（泌尿科医生）/科学家。该计划将在UW泌尿系管理，10个培训小组中有6个居住在UW泌尿系。一个核心课程的设计是为了教育医学博士和博士在与GU疾病有关的基本科学和临床问题。候选人还将在10个培训中心内获得一般和专业研究培训和机会，这些培训中心共有21名教师。10个培训组包括1）生物化学（PSA和相关丝氨酸蛋白酶的生物化学），2）勃起功能障碍（勃起功能和功能障碍的药理学、神经解剖学、生理学和分子生物学研究），3）GU病理学（涉及GU疾病特定病理学方面的研究，包括与泌尿肿瘤学和泌尿干细胞相关的研究;使用传统的病理学和基因组方法），4）传染病（毛滴虫和其他潜在前列腺炎病原体的分子生物学），5）男性生殖功能障碍（特发性精子功能障碍和前列腺炎的分子生物学和生理学），6）儿科泌尿学（泌尿道发育的分子生物学、体内平衡的维持和伤口修复），7）前列腺和膀胱干细胞（例如，使用CD抗原的表达谱鉴定和表征膀胱和前列腺中的干细胞），8）系统生物学，基因组学和遗传学（弗雷德哈钦森癌症研究中心和系统生物学研究所教师的联合活动，使用系统生物学的现代工具和方法解决与泌尿系统疾病和泌尿系统癌症有关的问题），9）移植（负责耐受性的机制和阻止临床转化的障碍），和10）泌尿肿瘤学（重点是与前列腺癌骨转移相关的转化和基础研究，雌激素对前列腺癌生长和模型开发的作用机制）。这些共同的和个性化的机会都是有组织的准备候选人在实验室和临床GU疾病研究的成功终身职业生涯

DESCRIPTION (provided by applicant): This training proposal seeks to recruit and train M.D.s, M.D./Ph.D.s, or Ph.D.s in research related to genitourinary (GU) diseases within the University of Washington (UW) clinical and research environment. M.D.s will be recruited from our urology residents prior to their PG4 research year and/or M.D.s who have finished their clinical residency training. Emphasis will be placed on recruiting potential physician (Urologists)/scientists. The program will be administered within the UW Department of Urology where 6 of the 10 training groups reside. A Core curriculum has been designed to educate both M.D.s and Ph.D.s in essential scientific and clinical concerns related to GU diseases. The candidates will also be given general and specialized research training and opportunities within the 10 training centers, which together entail 21 faculty. The 10 training groups include 1) Biochemistry (biochemistry of PSA and related serine proteases), 2) Erectile Dysfunction (pharmacological, neuroanatomical, physiological and molecular biological studies of erectile function and dysfunction), 3) GU Pathology (studies involving specific pathological aspects of GU disease, including those related to urologic oncology and urologic stem cells; use of traditional pathological and genomic approaches), 4) Infectious Disease (molecular biology of Trichomonas and other potential prostatitis pathogens), 5) Male Reproductive Dysfunction (molecular biology and physiology of idiopathic sperm dysfunction and of prostatitis), 6) Pediatric Urology (molecular biology of urinary tract development, maintenance of homeostasis and wound repair), 7) Prostate and Bladder Stem Cells (identification and characterization of stem cells in the bladder and prostate using, as an example, expression profiles of CD antigens), 8) Systems Biology, Genomics and Genetics (combined activities of faculty at the Fred Hutchinson Cancer Research Center and the Institute of Systems Biology to address issues related to urologic disease and urologic cancers using the modern tools and approaches of systems biology), 9) Transplantation (mechanisms responsible for tolerance and the barriers preventing clinical translation), and 10) Urologic Oncology (focused translational and basic studies related to prostate cancer bone metastasis, mechanisms of estrogen effects on prostate cancer growth and model development). These common and individualized opportunities are all organized to prepare the candidate for a successful life-long career in laboratory and clinical GU disease research