Bone Turnover and Fracture Risk in Men

尽管人们对男性骨质疏松症越来越感兴趣，但关于其发病机制和风险的数据却很少。 男性骨折的因素，或这一人群中有效的诊断策略。为了解决这些问题， 正在进行的男性骨质疏松症研究(MROS)成功地从6个人中招募了6000多名65岁以上的男性 美国临床中心。MRO收集了广泛的人体测量和健康习惯的基线测量， 以及轴向密度测量和腰椎侧位X线片。髋部和脊柱的基线QCT， 性激素是按不同的子集进行测量的。自基线访问以来，受试者一直被跟踪调查 对于新的骨折，截至2005年2月，46例髋部骨折和总共256例非脊柱骨折 骨折已被报道，并得到了中央裁决。研究参与者将返回临床中心 从2005年1月开始重复脊柱X光和密度测量，平均随访4.5年。 在这项MROS辅助研究中，我们计划使用基线和 提出一项前瞻性分析，研究骨转换与椎体、髋关节和任何 非脊柱骨折采用有效的嵌套病例队列研究设计。我们的抽样计划将需要 利用现有的许多MRO测量方法，包括DXA、QCT和性激素水平。在……里面 此外，我们还将分析一种新的无创性骨胶原生化指标之间的关系 质量，1型胶原异构化，以及脊柱、髋部和任何非脊柱骨折。前景 对老年女性的研究表明，骨骼转换和胶原蛋白异构化都是独立的 与骨折风险有关，但这种关系尚未在男性中进行研究。最后，我们计划研究 骨转换和骨丢失，并确定哪些人体测量、历史和健康习惯因素 与骨骼周转有关。这些分析将解决有关该病发病机制的关键问题。 男性脊柱和非脊柱骨折，并将确定骨转换测量的临床应用 这群人。

Despite growing interest about osteoporosis in men, there is little data regarding the pathogenesis and risk factors for fracture in men, or effective diagnostic strategies in this population. To address these issues, the ongoing Osteoporosis in Men Study (MrOS) has successfully recruited over 6000 men over age 65 from 6 US clinical centers. MrOS collected extensive baseline measurements of anthropometric and health habits, as well as axial densitometry and lateral lumbosacral spine radiographs. Baseline QCT of the hip and spine, and sex hormones have been measured in subsets. Since the baseline visit, subjects have been followed for the occuence of new fractures, and as of Feburary 2005, 46 hip fractures and a total of 256 non-spine fractures have been reported and centrally adjudicated. Study participants will return to the clinical centers for repeat spine x-rays and densitometry beginning January, 2005, after a mean follow-up of 4.5 years. In this MrOS ancillary study, we plan to use archived serum and urine specimens from baseline and propose a prospective analysis of the relationship between bone turnover and incident vertebral, hip and any non-spine fracture using an efficient nested case-cohort study design. Our sampling scheme will take advantage of the many existing measurements in MrOS, including DXA, QCT and sex hormone levels. In addition, we will analyze the relationship between a new non-invasive biochemical index of bone collagen quality, type 1 collagen isomerization, and incident vertebral, hip and any non-spine fracture. Propective studies among older women suggest that both bone turnover and collage isomerization are independently associated with fracture risk, but such relationships have not been studied in men. Lastly, we plan to study bone turnover and bone loss, and determine which anthropometric, historical and health habit factors are associated with bone turnover. These analyses will address critical questions about the pathogenesis of spine and non-spine fracture in men, and will determine the clinical utility of bone turnover measurements in this population.