Managing obesity by combining behavioral weight loss and commercial approaches

描述(由申请人提供)： 这项以患者为导向的导师研究职业奖(K23)的目标是为Angela Pinto博士提供发展所需专业知识的机会，以成为一名研究具有成本效益的肥胖症行为疗法的独立科学家。该培训计划概述了授课和直接指导培训经验的结合，将为Pinito博士提供在以下领域发展和提高技能的机会：肥胖和肥胖治疗的公共健康模型；体重调节的行为方法；临床肥胖研究的方法、统计学和伦理学；以及成本效益分析的标准和技术及其在行为减肥试验中的应用。在整个颁奖过程中，平托博士将与她的主要导师雷纳·荣博士以及她的共同导师威廉·赫尔曼博士、马克·施莱尼茨博士、约瑟夫·法瓦博士和罗伯特·杰弗里博士密切合作。米里亚姆医院/布朗医学院的资源，再加上她的指导团队的专业知识，将为平托博士提供实现她的培训和研究目标的理想环境。在美国，肥胖是一个主要的公共健康问题。基于大学/医院的行为减肥计划是中度肥胖的黄金标准，但它们的运行成本很高，而且大多数寻求减肥的人获得的机会有限。商业减肥计划提供得到广泛认可、易于获得和负担得起的治疗，但产生的减肥效果明显低于基于大学/医院的治疗。肥胖症流行的范围要求对想要减肥的人来说，行为减肥治疗既临床有效，又具有成本效益。因此，这项研究的目的是开发和评估一种具有成本效益的肥胖治疗方法，将行为减肥干预的临床有效性与Weight Watcher商业计划的可及性相结合。在这项为期12个月的试验中，198名体重指数在27-40之间的男性和女性将被随机分配到接受标准行为减肥、慧俪轻体或联合治疗。这项研究的长期目标是通过增加基于大学/医院的行为减肥计划和商业减肥组织之间的合作，扩大具有成本效益的肥胖治疗的公共健康覆盖范围。

DESCRIPTION (provided by applicant): The goal of this Mentored Patient-Oriented Research Career Award (K23) is to provide Dr. Angela Pinto with the opportunity to develop the expertise needed to become an independent scientist studying cost-effective behavioral treatments for obesity. This training plan outlines a combination of didactic and direct mentored training experiences that will provide Dr. Pinito with the opportunity to develop and enhance skills in the following areas: the public health model of obesity and obesity treatment; behavioral approaches to weight regulation; methodology, statistics, and ethics of clinical obesity research; and the standards and techniques of cost-effectiveness analysis and their application to behavioral weight loss trials. Dr. Pinto will work closely with her primary mentor, Dr. Rena Wing, and her co-mentors, Drs. William Herman, Mark Schleinitz, Joseph Fava, and Robert Jeffery, throughout the course of this award. The resources at the Miriam Hospital/Brown Medical School, combined with the expertise of her mentoring team will provide Dr. Pinto with the ideal environment in which to achieve her training and research goals. Obesity is a major public health problem in the United States. University/hospital-based behavioral weight loss programs are the gold standard for moderate obesity, but they are costly to run and have limited accessibility to the majority of individuals seeking weight loss. Commercial weight loss programs offer widely recognized, highly accessible, and affordable treatment, but produce weight losses that are markedly less than those achieved in university/hospital based treatment. The scope of the obesity epidemic demands behavioral weight loss treatment that is both clinically effective and cost-effective for individuals who want to lose weight. Therefore, the purpose of this investigation is to develop and evaluate a cost-effective treatment for obesity that integrates the clinical effectiveness of behavioral weight loss interventions with the accessibility of the Weight Watchers commercial program. In this 12-month trial, 198 men and women with a BMI of 27-40 will be randomly assigned to receive standard behavioral weight loss, Weight Watchers, or a combination treatment. The long-term goal of this research is to expand the public health reach of cost-effective obesity treatment through increased collaboration between university/hospital-based behavioral weight loss programs and commercial weight loss organizations.