Optical Anion Sensing Using Templated and Surface Assembled Interlocked Cavities

有强烈的电流感兴趣的设计和合成的受体，是在检测溶液中的阴离子熟练。该项目旨在构建新型表面连接的互锁“宿主”分子，这些分子被设计为在单个分子宿主框架内高度特异性地结合带负电荷的客体物种（磷酸盐和氯化物）。将光学信号传导或报告基团并入主体腔中，使得客体选择性地紧密接近该光学敏感基团，并且在主体-客体结合时发生响应。使用客体阴离子充当模板以在其周围组装主体腔，其中主体结合位点由围绕轴缠绕的轮组成，导致阴离子模板的理想三维的独特拓扑腔。该模板可以被选择为感测例如氯化物的靶物质。将所得分子主体系统附着到表面上，然后除去模板阴离子，导致产生光学传感装置材料，其将对目标带负电荷物质表现出前所未有的选择性和灵敏度。

There is intense current interest being shown in the design and syntheses of receptors that are proficient at detecting anions in solution. This project aims to construct novel surface attached interlocked 'host' molecules that are designed to bind, highly specifically, negatively charged guest species (phosphate and chloride) within a single molecular host framework. The optical signalling or reporter group is incorporated into the host cavity such that the guest selectively fits in close proximity to this optically sensitive group and a response occurs on host-guest binding. Using the guest anion to act as a template to assemble a host cavity around it, where the host binding site consists of a wheel wrapping around an axle, results in a unique topological cavity of ideal three dimensions for the anion template. This template can be chosen to be a target species to sense eg chloride. Attaching the resultant molecular host system to a surface followed by removal of the templating anion leads to the production of an optical sensing device material that will exhibit unprecedented selectivity and sensitivity towards targeted negatively charged species.