Optical Anion Sensing Using Templated and Surface Assembled Interlocked Cavities

目前，人们对擅长检测溶液中阴离子的受体的设计和合成表现出了浓厚的兴趣。该项目旨在构建新的表面附着、互锁的‘宿主’分子，其设计目的是在单个分子宿主框架内高度具体地化地结合带负电荷的客体物种(磷酸盐和氯化物)。光学信令或报告基团被结合到主腔中，使得客体选择性地与该光学敏感基团紧密配合，并且在主-客体结合上发生响应。使用客体阴离子作为模板在其周围组装主体空腔，其中主体结合位置由包裹在轴上的轮子组成，从而为阴离子模板产生理想的三维独特的拓扑腔。可以选择该模板作为检测例如氯化物的目标物种。将生成的分子主体系统附着在表面上，然后去除模板阴离子，从而产生一种光学传感器件材料，该材料将对目标负电荷物种表现出前所未有的选择性和灵敏度。

There is intense current interest being shown in the design and syntheses of receptors that are proficient at detecting anions in solution. This project aims to construct novel surface attached interlocked 'host' molecules that are designed to bind, highly specifically, negatively charged guest species (phosphate and chloride) within a single molecular host framework. The optical signalling or reporter group is incorporated into the host cavity such that the guest selectively fits in close proximity to this optically sensitive group and a response occurs on host-guest binding. Using the guest anion to act as a template to assemble a host cavity around it, where the host binding site consists of a wheel wrapping around an axle, results in a unique topological cavity of ideal three dimensions for the anion template. This template can be chosen to be a target species to sense eg chloride. Attaching the resultant molecular host system to a surface followed by removal of the templating anion leads to the production of an optical sensing device material that will exhibit unprecedented selectivity and sensitivity towards targeted negatively charged species.