Human RIPC-derived Regulatory Molecules for Cardioprotection against Ischemic and Cardiopulmonary Bypass Injury

我们以前的工作表明，当远程对肢体施加短暂的应激(远程缺血预适应)时，诱发的人类血液传播因子可以保护心肌免受由于血流丧失而造成的损伤。我们已经确定了这些蛋白质，它们似乎激活了适应性细胞生存过程的遗传和代谢调节。我们现在将使用细胞和临床模型来测试它们在心脏中的单独和组合能力、效率和保护机制。

Our previous work indicates that evoked human blood borne factors confer protection against injury, due to loss of blood flow in heart muscle, when a brief stress is remotely applied to a limb (remote ischemic preconditioning). We have identified these proteins that appear to activate genetic and metabolic regulation of adaptive cell survival processes. We will now test their individual and combined capacity, efficiency and mechanisms of protection in the heart using cell and clinical models.