DF/HCC SPORE in Gastrointestinal Cancer

描述（由申请人提供）：本申请代表了源自Dana- Farber/哈佛癌症中心（DF/HCC）胃肠道（GI）肿瘤项目的胃肠道癌症卓越研究专业项目（SPORE）的创建。GI癌症中DF/HCC SPORE的主要目标是将生物学和技术进步转化为预防、诊断、结果预测的改进以及胃肠道恶性肿瘤治疗的进展。GI癌症中的DF/HCC SPORE包括来自所有哈佛附属医院的研究人员：Dana-Farber癌症研究所、布里格姆妇女医院、马萨诸塞州总医院、贝斯以色列女执事医疗中心、波士顿儿童医院和哈佛公共卫生学院。提出了五个主要项目，包括：1）改善胰腺癌的术前分期; 2）早期发现结直肠肿瘤的分子荧光成像; 3）确定黑人化学预防的最佳维生素D剂量; 4）PI 3-激酶信号通路在确定结直肠癌抗EGFR治疗敏感性和耐药性中的作用;胃肠道间质瘤靶向治疗耐药机制的研究。这些项目将通过创建四个核心来整合：1）管理，评估和规划; 2）组织和病理学; 3）生物统计学和4）基因组学和生物信息学。SPORE应用程序概述了一个发展项目计划，其中包括一个新项目的选择计划以及九个可以支持的试点项目。我们还包括一个职业发展奖励计划，概述了一个机制，用于识别和支持有才华的年轻研究人员在GI癌症。本申请中提出的项目和核心与当前DF/HCC核心资源高度集成，并涉及与其他现有SPORE研究人员的关键合作。在DF/HCC创建这个GI SPORE将联合收割机将基础、转化和临床科学领域的领先哈佛研究人员结合到一个项目中，该项目具有在GI癌症的诊断、治疗和预防方面产生有意义的进展所需的重点和协调。

DESCRIPTION (provided by applicant): This application represents the creation of a Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer originating from the Gastrointestinal (Gl) Malignancies Program of the Dana- Farber/Harvard Cancer Center (DF/HCC). The main goal of the DF/HCC SPORE in Gl Cancer is the translation of biological and technological advances into improvements in prevention, diagnostics, predictors of outcome, and advances in the treatment of gastrointestinal malignancies. The DF/HCC SPORE in Gl Cancer includes researchers from all Harvard-affiliated hospitals: the Dana-Farber Cancer Institute, the Brigham and Women's Hospital, the Massachusetts General Hospital, the Beth Israel Deaconess Medical Center, Children's Hospital of Boston, and Harvard School of Public Health. Five major projects are proposed including: 1) Improved pre-operative staging of pancreatic cancer; 2) Molecular fluorescent imaging for the early detection of colorectal neoplasms; 3) Defining optimal doses of vitamin D for chemoprevention in Blacks; 4) The role of PI3-Kinase signaling pathway in defining sensitivity and resistance to anti-EGFR therapy in colorectal cancer; and 5) Targeted therapy resistance mechanisms in gastrointestinal stromal tumor. These projects will be integrated by the creation of four cores: 1) Administration, Evaluation & Planning; 2) Tissue and Pathology; 3) Biostatistics and 4) Genomics and Bioinformatics. The SPORE application outlines a Developmental Projects Program that includes a plan for selection of new projects as well as nine pilot projects that could be supported. We also include a Career Development Award Program that outlines a mechanism for the identification and support of talented young investigators in Gl cancer. The projects and cores proposed in this application are highly integrated with present DF/HCC core resources, and involve key collaborations with investigators from other existing SPOREs. The creation of this Gl SPORE at DF/HCC will combine leading Harvard researchers in basic, translational, and clinical sciences into a program that has the focus and coordination required to produce meaningful advances in the diagnosis, treatment, and prevention of Gl cancers.