Administration, Evaluation, and Planning

该应用程序代表了卓越研究的专业计划（SPORE）的创建， 起源于Dana胃肠（GI）肿瘤计划的胃肠癌- Farber/哈佛癌症中心（DF/HCC）。GI癌症中DF/HCC孢子的主要目标是 将生物和技术进步转化为预防、诊断、预测 的结果，并在胃肠道恶性肿瘤的治疗进展。GI中DF/HCC孢子 癌症包括来自所有哈佛附属医院的研究人员：达纳法伯癌症研究所， 布里格姆妇女医院、马萨诸塞州总医院、贝斯以色列女执事医疗中心 中心，波士顿儿童医院和哈佛公共卫生学院。五大项目是 建议包括：1）改善胰腺癌的术前分期; 2）分子荧光 结肠直肠肿瘤的早期检测成像; 3）确定维生素D的最佳剂量， 4）PI 3-激酶信号通路在确定敏感性和抗性中的作用 结直肠癌中的抗EGFR治疗;和5）结直肠癌中的靶向治疗抗性机制。 胃肠道间质瘤这些项目将通过创建四个核心来整合：1） 管理、评估和规划; 2）组织和病理学; 3）生物统计学和4）基因组学和 生物信息学。SPORE应用程序概述了开发项目计划，其中包括计划或 选择新的项目以及九个可以得到支持的试点项目。我们还包括职业生涯 发展奖励计划，概述了一种发现和支持有才华的年轻人的机制 GI癌症的研究人员。本申请中提出的项目和核心与 呈现DF/HCC核心资源，并与其他现有研究人员进行关键合作 孢子。在DF/HCC创建这个GI孢子将联合收割机结合领先的哈佛研究人员在基础， 转化，临床科学到一个程序，有重点和协调所需的生产 在GI癌症的诊断、治疗和预防方面的有意义的进展。

This application represents the creation of a Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer originating from the Gastrointestinal (Gl) Malignancies Program of the Dana- Farber/Harvard Cancer Center (DF/HCC). The main goal of the DF/HCC SPORE in Gl Cancer is the translation of biological and technological advances into improvements in prevention, diagnostics, predictors of outcome, and advances in the treatment of gastrointestinal malignancies. The DF/HCC SPORE in Gl Cancer includes researchers from all Harvard-affiliated hospitals: the Dana-Farber Cancer Institute, the Brigham and Women's Hospital, the Massachusetts General Hospital, the Beth Israel Deaconess Medical Center, Children's Hospital of Boston, and Harvard School of Public Health. Five major projects are proposed including: 1) Improved pre-operative staging of pancreatic cancer; 2) Molecular fluorescent imaging for the early detection of colorectal neoplasms; 3) Defining optimal doses of vitamin D for chemoprevention in Blacks; 4) The role of PI3-Kinase signaling pathway in defining sensitivity and resistance to anti-EGFR therapy in colorectal cancer; and 5) Targeted therapy resistance mechanisms in gastrointestinal stromal tumor. These projects will be integrated by the creation of four cores: 1) Administration, Evaluation & Planning; 2) Tissue and Pathology; 3) Biostatistics and 4) Genomics and Bioinformatics. The SPORE application outlines a Developmental Projects Program that includes a plan or selection of new projects as well as nine pilot projects that could be supported. We also include a Career Development Award Program that outlines a mechanism for the identification and support of talented young investigators in Gl cancer. The projects and cores proposed in this application are highly integrated with present DF/HCC core resources, and involve key collaborations with investigators from other existing SPOREs. The creation of this Gl SPORE at DF/HCC will combine leading Harvard researchers in basic, translational, and clinical sciences into a program that has the focus and coordination required to produce meaningful advances in the diagnosis, treatment, and prevention of Gl cancers.