Clinical Hematology Research Career Development Program at Washington University

描述(由申请人提供)： 华盛顿大学临床血液学研究职业发展计划的目标是开发和评估一个多学科的职业发展计划，为学员(学者)解决非恶性血液疾病的复杂问题做好准备。学者将是临床或研究研究员，临床或研究讲师，或最近任命的助理教授。学者们有望成为非恶性临床血液学的独立研究人员和领导者。在第一年，学者们将继续学习临床核心课程，包括住院和门诊护理特定的非恶性血液疾病患者，以及教授独立和伦理临床研究所需技能的教学临床研究课程。这个一年级的课程将利用现有的K30课程和华盛顿大学在生物统计学、流行病学和临床研究方面的学位授予计划的优势。在第一年接近尾声时，每位奖学金获得者将开始为期一到两年的强化导师研究体验，以产生可发表的结果和初步数据，供随后的独立拨款申请使用。该计划将重点关注非恶性血液病的三个主要领域：(1)骨髓衰竭综合征，包括阵发性睡眠性血红蛋白尿、再生障碍性贫血、先天性贫血和骨髓增生异常综合征；(2)止血和血栓性疾病，包括血管性血友病、血栓性微血管病和其他先天性或获得性出血性或血栓性综合征；(3)镰状细胞病和其他血红蛋白疾病。这些研究项目将涵盖患有非恶性血液疾病的儿科、青少年和成人受试者。在这些目标中，我们承诺招募来自不同背景的杰出学者，根据他们的需求和经验对他们进行个性化培训，不断监测和改进课程，并跟踪学者的表现。通过这些手段，拟议的职业发展计划将提高我们在非恶性临床血液学方面的转化性、多学科研究的国家能力，并缓解这一医学重要学科的学术内科科学家的短缺。

DESCRIPTION (provided by applicant): The objectives of the Clinical Hematology Research Career Development Program at Washington University are to develop and evaluate a multidisciplinary career development program that will prepare trainees (Scholars) to address complex problems in non-malignant blood diseases. Scholars will be clinical or research fellows, clinical or research instructors, or recently appointed assistant professors. Scholars are expected to become independent researchers and assume leadership roles in non-malignant clinical hematology. During the first year, Scholars will pursue a Clinical Core Curriculum that involves inpatient and outpatient care of patients with specific non-malignant hematologic disorders, and a Didactic Clinical Research Curriculum that teaches the skills necessary for independent and ethical clinical research. This first-year curriculum will draw on the strengths of existing K30 and degree granting programs in biostatistics, epidemiology, and clinical research at Washington University. Toward the end of the first year, each Scholar will begin a one or two year intensive Mentored Research Experience to generate publishable results and preliminary data for subsequent independent grant applications. The program will focus on three major areas of non-malignant hematologic disease: (1) bone marrow failure syndromes, including paroxysmal nocturnal hemoglobinuria, aplastic anemia, congenital anemias, and myleodysplastic syndrome; (2) hemostatic and thrombotic disorders, including von Willebrand disease, thrombotic microangiopathy, and other congenital or acquired hemorrhagic or thrombotic syndromes; and (3) sickle cell disease and other hemoglobinopathies. These research projects will encompass pediatric, adolescent and adult subjects with non-malignant hematologic disorders. Implicit in these objectives is our commitment to recruit outstanding Scholars from diverse backgrounds, to individualize their training based on their needs and experience, to continuously monitor and improve the curriculum, and to track Scholar performance. By these means, the proposed career development program will increase our national capacity for translational, multidisciplinary research in non-malignant clinical hematology and alleviate the shortage of academic physician-scientists in this medically important discipline.