PROJECT/ EXPLORATORY STUDIES CORE

试点/探索性研究核心（PESC）的主要目标是促进创新的发展， 和方法上严谨的研究，旨在提高我们对病因的理解， 诊断，治疗和预防多因素老年健康状况（耶鲁大学的声明重点 OAIC.1），最终导致制定有效和具有成本效益的干预措施， 让美国老年人保持独立。具体目标是： (1)征求和选择最有价值的研究建议，以获得PESC的资助; (2)为PESC研究的研究者提供从其他OAIC核心获得资源的机会; (3)确定共同赞助PESC研究的潜在机会; (4)确定PESC研究者之间合作的潜在机会; (5)监察公众教育谘询委员会研究的进展; (6)提供援助，使PESC研究能够成功地发展成为独立资助的项目， 补助金申请; (7)确保入组PESC研究的人类受试者的安全性和保护;以及 (8)确保PESC的研究招收了相当大比例的代表性不足的少数民族。 PESC将为研究人员提供一个宝贵的机制，以获得有希望的初步数据。 采用多因素方法的基础科学、转化、临床、流行病学和干预研究 老年健康状况的研究。这些研究调查的是 导致许多健康状况的多种诱发和诱发因素 影响到老年人，而老年人又对健康的多个领域产生影响。资助的研究 公共电子商务中心将充分利用来自实地、数据管理、 信息学和生物统计学核心。PESC资金的优先权也将给予初级研究人员 对于那些希望将研究方向转向或扩展到 多因素老年健康状况研究。

The primary goal of the Pilot/Exploratory Studies Core (PESC) is to facilitate the development of innovative and methodologically rigorous research studies designed to enhance our understanding of the etiology, diagnosis, treatment, and prevention of multifactorial geriatric health conditions (the stated focus of the Yale OAIC.1), leading ultimately to the development of efficacious and cost-effective interventions to increase or maintain independence for older Americans. The specific aims are: (1) to solicit and select the most meritorious research proposals for PESC funding; (2) to provide investigators of PESC studies with access to resources from the other OAIC Cores; (3) to identify potential opportunities for co-sponsorship of PESC studies; (4) to identify potential opportunities for collaboration among PESC investigators; (5) to monitor the progress of the PESC studies; (6) to provide assistance so that the PESC studies can be successfully developed into independently funded grant applications; (7) to ensure the safety and protection of human subjects enrolled in PESC studies; and (8) to ensure that PESC studies enroll a substantial proportion of underrepresented minorities. The PESC will provide an invaluable mechanism for investigators to obtain preliminary data for promising basic science, translational, clinical, epidemiologic and intervention studies taking a multifactorial approach to the study of geriatric health conditions. Such studies investigate the interactions among or intervene on the multiple predisposing and precipitating factors that are responsible for many of the health conditions affecting older persons, which, in turn, have effects on multiple domains of health..Studies funded through the PESC will take full advantage of the resources and expertise available from the Field, Data Management & Informatics, and Biostatistics Cores. Priority for PESC funding will be given to junior investigators as well as to accomplished mid career and senior investigators who wish to redirect or expand their research to the study of multifactorial geriatric health conditions.