Mucosal Immunology Core

黏膜免疫学核心实验室(MICL)于1998年首次提出并获得资金，原因是 越来越多的人意识到，粘膜淋巴组织作为艾滋病毒感染的宿主是至关重要的。 据我们所知，这是CFAR中第一个此类核心设施，并将继续是一项独特的资源 全国范围内。感兴趣的研究人员几乎无法接触到新获得的组织，而且没有经过验证的 用于量化组织HIV病毒载量以及其他相关粘膜免疫学和病毒学的分析 记号笔。自从4.5年前开始最近一次CFAR更新以来，MICL已经收集了超过8000 来自362名受试者的粘膜组织活组织检查。另外407次MICL会议包括235个主题 无需活组织检查的筛查、献血或精液捐献探访和172个组织样本 从组织采购核心实验室收到的化验或组织标本的合作者 (TPCL)。此外，MICL还支持了21名研究人员(8名非加州大学洛杉矶分校)，21项赠款申请(16项资助)，以及 在过去的两年中，MICL开发了317名潜在受试者的临床试验注册 根据需要进行主动招聘。这种资源在任何地方都是无与伦比的，是非常独特的CFAR 艾滋病毒调查人员的资源。

The Mucosal Immunology Core Laboratory (MICL) was first proposed and funded in 1998 due to an emerging awareness that mucosal lymphoid tissues were critically important as a reservoir for HIV infection. To our knowledge, this was the first Core facility of its kind in CFAR and continues to be a unique resource nationally. Interested researchers had little access to freshly acquired tissue and there were no validated assays for quantifying tissue HIV viral burden as well as other relevant mucosal immunologic and virologic markers. Since the start of the most recent CFAR renewal 4.5 years ago, the MICL has collected over 8000 mucosal tissue biopsies for study from 362 subjects. An additional 407 MICL encounters include 235 subject visits for screening, blood or semen donation without biopsies and 172 tissue specimens received from collaborators for assays or tissue specimens received from the Tissue Procurement Core Laboratory (TPCL). Also the MICL has supported 21 researchers (8 non-UCLA), 21 grant applications (16 funded), and during the past 2 years the MICL has developed a Clinical Trial Registry of 317 potential subjects for proactive recruitment as needed. This resource in unmatched anywhere and is a very unique CFAR resource for HIV investigators.