Prenatal Ultrasound And Birth Defects

描述(申请人提供)：这项研究将评估在怀孕13至28周期间进行产前超声检查的敏感性和特异性，以检测大约38种不同的胎儿结构畸形。目前，关于社区环境中的这些检测率的现有证据很少。因此，这些信息将立即用于医生和孕妇，帮助他们在以下方面做出明智的选择：1)常规产前超声检查的有用性；2)先天性异常阴性的超声检查的准确性；3)先天性异常阳性的超声检查的准确性。我们计划创建一个由7.6万名女性组成的多种族队列，她们在1998至2006年间在休斯顿的德克萨斯大学医学院进行了产前超声检查。超声波检查的计算机化记录将与出生证明和胎儿死亡证明联系起来。它们还将与德克萨斯州出生缺陷登记处的记录联系起来，这是一个活跃的、基于人口的登记处，由德克萨斯州卫生服务部管理。这项拟议的研究将包括大约1450名患有结构畸形的婴儿。这将是关于产前超声检测先天性异常能力的最具统计学效力的研究之一。将对38种不同类型的畸形进行敏感性和特异性的评估。

DESCRIPTION (provided by applicant): This study will assess the sensitivity and specificity of prenatal ultrasound performed between 13 and 28 weeks of gestation to detect approximately 38 different structural malformations of the fetus. Currently, there is little available evidence concerning these detection rates in the community setting. Thus, this information will be of immediate use to physicians and pregnant women, assisting them in making informed choices concerning; 1) the usefulness of routine prenatal ultrasound examinations 2) the accuracy of ultrasound examinations that are negative for congenital anomalies and 3) the accuracy of ultrasound examinations that are positive for congenital anomalies. We plan to create a multi-ethnic cohort of 76,000 women who had prenatal ultrasound exams at the University of Texas Medical School at Houston between 1998 and 2006. Computerized records of ultrasound examinations will be linked with birth certificates and fetal death certificates. They will also be linked with records of the Texas Birth Defects Registry, an active, population based registry, administered by the Texas Department of State Health Services. The proposed study will include an estimated 1,450 infants with structural malformations. This will be one of the most statistically powerful studies of the ability of prenatal ultrasound to detect congenital anomalies. Estimates of sensitivity and specificity will be calculated for each of 38 different categories of malformations.